2l38: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l38 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l38 RCSB], [http://www.ebi.ac.uk/pdbsum/2l38 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l38 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l38 RCSB], [http://www.ebi.ac.uk/pdbsum/2l38 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/ACTP2_STOHE ACTP2_STOHE]] Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes cardiac stimulation and hemolysis. Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of several monomers. Cytolytic effects include red blood cells hemolysis, platelet aggregation and lysis, cytotoxic and cytostatic effects on fibroblasts. Lethality in mammals has been ascribed to severe vasospasm of coronary vessels, cardiac arrhythmia, and inotropic effects.<ref>PMID:10978735</ref> <ref>PMID:11478962</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | ||
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== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Stichodactyla helianthus]] | [[Category: Stichodactyla helianthus]] | ||
[[Category: Alegre-Cebollada, J | [[Category: Alegre-Cebollada, J]] | ||
[[Category: Bruix, M | [[Category: Bruix, M]] | ||
[[Category: Castrillo, I | [[Category: Castrillo, I]] | ||
[[Category: Gavilanes, J | [[Category: Gavilanes, J]] | ||
[[Category: Martinez-del-Pozo, A | [[Category: Martinez-del-Pozo, A]] | ||
[[Category: Actinoporin]] | [[Category: Actinoporin]] | ||
[[Category: Pore forming toxin]] | [[Category: Pore forming toxin]] | ||
[[Category: Sticholysin]] | [[Category: Sticholysin]] | ||
[[Category: Toxin]] | [[Category: Toxin]] | ||