2wf9: Difference between revisions

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 <StructureSection load='2wf9' size='340' side='right' caption='[[2wf9]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2wf9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lactococcus_lactis Lactococcus lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF9 OCA]. <br>
+<table><tr><td colspan='2'>[[2wf9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lactococcus_lactis Lactococcus lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WF9 FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=BG6:BETA-D-GLUCOSE-6-PHOSPHATE'>BG6</scene>, <scene name='pdbligand=G6P:ALPHA-D-GLUCOSE-6-PHOSPHATE'>G6P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=BG6:BETA-D-GLUCOSE-6-PHOSPHATE'>BG6</scene>, <scene name='pdbligand=G6P:ALPHA-D-GLUCOSE-6-PHOSPHATE'>G6P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1z4o|1z4o]], [[1o03|1o03]], [[1zol|1zol]], [[1z4n|1z4n]], [[1o08|1o08]], [[1lvh|1lvh]], [[2wf5|2wf5]], [[2wf6|2wf6]], [[2wf7|2wf7]], [[2wf8|2wf8]], [[2wfa|2wfa]]</td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1z4o|1z4o]], [[1o03|1o03]], [[1zol|1zol]], [[1z4n|1z4n]], [[1o08|1o08]], [[1lvh|1lvh]], [[2wf5|2wf5]], [[2wf6|2wf6]], [[2wf7|2wf7]], [[2wf8|2wf8]], [[2wfa|2wfa]]</td></tr>
-<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-phosphoglucomutase Beta-phosphoglucomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.6 5.4.2.6] </span></td></tr>
-<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wf9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wf9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wf9 RCSB], [http://www.ebi.ac.uk/pdbsum/2wf9 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wf9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wf9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wf9 RCSB], [http://www.ebi.ac.uk/pdbsum/2wf9 PDBsum]</span></td></tr>
-<table>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/PGMB_LACLA PGMB_LACLA]] Catalyzes the interconversion of D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), forming beta-D-glucose 1,6-(bis)phosphate (beta-G16P) as an intermediate. The beta-phosphoglucomutase (Beta-PGM) acts on the beta-C(1) anomer of G1P. Glucose or lactose are used in preference to maltose, which is only utilized after glucose or lactose has been exhausted. It plays a key role in the regulation of the flow of carbohydrate intermediates in glycolysis and the formation of the sugar nucleotide UDP-glucose.<ref>PMID:9084169</ref> <ref>PMID:15005616</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
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 Near attack conformers dominate beta-phosphoglucomutase complexes where geometry and charge distribution reflect those of substrate.,Griffin JL, Bowler MW, Baxter NJ, Leigh KN, Dannatt HR, Hounslow AM, Blackburn GM, Webster CE, Cliff MJ, Waltho JP Proc Natl Acad Sci U S A. 2012 May 1;109(18):6910-5. Epub 2012 Apr 13. PMID:22505741<ref>PMID:22505741</ref>
-From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+==See Also==
+*[[Beta-phosphoglucomutase|Beta-phosphoglucomutase]]
 == References ==
 <references/>
@@ Line 32: / Line 37: @@
 [[Category: Beta-phosphoglucomutase]]
 [[Category: Lactococcus lactis]]
-[[Category: Alizadeh, T.]]
+[[Category: Alizadeh, T]]
-[[Category: Baxter, N J.]]
+[[Category: Baxter, N J]]
-[[Category: Bermel, W.]]
+[[Category: Bermel, W]]
-[[Category: Blackburn, G M.]]
+[[Category: Blackburn, G M]]
-[[Category: Bowler, M W.]]
+[[Category: Bowler, M W]]
-[[Category: Cliff, M J.]]
+[[Category: Cliff, M J]]
-[[Category: Hollfelder, F.]]
+[[Category: Hollfelder, F]]
-[[Category: Hounslow, A M.]]
+[[Category: Hounslow, A M]]
-[[Category: Pollard, S.]]
+[[Category: Pollard, S]]
-[[Category: Waltho, J P.]]
+[[Category: Waltho, J P]]
-[[Category: Webster, C E.]]
+[[Category: Webster, C E]]
-[[Category: Williams, N H.]]
+[[Category: Williams, N H]]
 [[Category: Ground state analogue]]
 [[Category: Haloacid dehalogenase superfamily]]