3lxx: Difference between revisions

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lxx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lxx RCSB], [http://www.ebi.ac.uk/pdbsum/3lxx PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lxx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lxx RCSB], [http://www.ebi.ac.uk/pdbsum/3lxx PDBsum]</span></td></tr>
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== Function ==
[[http://www.uniprot.org/uniprot/GIMA4_HUMAN GIMA4_HUMAN]] May play a role in regulating lymphocyte apoptosis (By similarity). Exhibits intrisinic GTPase activity. Shows a higher affinity for GDP over GTP (about 12-fold higher), and binding shows an absolute requirement for magnesium.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 21:29, 24 December 2014

Crystal structure of human GTPase IMAP family member 4Crystal structure of human GTPase IMAP family member 4

Structural highlights

3lxx is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
NonStd Res:
Gene:GIMAP4, IAN1, IMAP4, MSTP062 (Homo sapiens)
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[GIMA4_HUMAN] May play a role in regulating lymphocyte apoptosis (By similarity). Exhibits intrisinic GTPase activity. Shows a higher affinity for GDP over GTP (about 12-fold higher), and binding shows an absolute requirement for magnesium.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

3lxx, resolution 2.15Å

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