1ypy: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1ypy.gif|left|200px]] | [[Image:1ypy.gif|left|200px]] | ||
'''Crystal Structure of Vaccinia Virus L1 protein''' | {{Structure | ||
|PDB= 1ypy |SIZE=350|CAPTION= <scene name='initialview01'>1ypy</scene>, resolution 1.510Å | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= | |||
|GENE= L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10245 Vaccinia virus]) | |||
}} | |||
'''Crystal Structure of Vaccinia Virus L1 protein''' | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
1YPY is a [ | 1YPY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YPY OCA]. | ||
==Reference== | ==Reference== | ||
The 1.51-Angstrom structure of the poxvirus L1 protein, a target of potent neutralizing antibodies., Su HP, Garman SC, Allison TJ, Fogg C, Moss B, Garboczi DN, Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4240-5. Epub 2005 Mar 10. PMID:[http:// | The 1.51-Angstrom structure of the poxvirus L1 protein, a target of potent neutralizing antibodies., Su HP, Garman SC, Allison TJ, Fogg C, Moss B, Garboczi DN, Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4240-5. Epub 2005 Mar 10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15761054 15761054] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Vaccinia virus]] | [[Category: Vaccinia virus]] | ||
| Line 25: | Line 34: | ||
[[Category: variola virus]] | [[Category: variola virus]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:25:58 2008'' | ||
Revision as of 16:25, 20 March 2008
| |||||||
| , resolution 1.510Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | L1 (Vaccinia virus) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of Vaccinia Virus L1 protein
OverviewOverview
Although eradicated from nature more than two decades ago, the threat of smallpox has reemerged because of concerns over its use as a biological weapon. We present the structure of the poxvirus L1 protein, a molecule that is conserved throughout the poxvirus family and is nearly identical in vaccinia virus and in variola virus, which causes smallpox. L1 is a myristoylated envelope protein that is a potent target for neutralizing antibodies and an important component of current experimental vaccines. The L1 structure reveals a hydrophobic cavity located adjacent to its N terminus. The cavity would be capable of shielding the myristate moiety, which is essential for virion assembly. The structure of L1 is a step in the elucidation of molecular mechanisms common to all poxviruses that may stimulate the design of safer vaccines and new antipoxvirus drugs.
About this StructureAbout this Structure
1YPY is a Single protein structure of sequence from Vaccinia virus. Full crystallographic information is available from OCA.
ReferenceReference
The 1.51-Angstrom structure of the poxvirus L1 protein, a target of potent neutralizing antibodies., Su HP, Garman SC, Allison TJ, Fogg C, Moss B, Garboczi DN, Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4240-5. Epub 2005 Mar 10. PMID:15761054
Page seeded by OCA on Thu Mar 20 15:25:58 2008