4avc: Difference between revisions

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 == Structural highlights ==
 <table><tr><td colspan='2'>[[4avc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AVC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AVC FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene><br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ava|4ava]], [[4avb|4avb]]</td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ava|4ava]], [[4avb|4avb]]</td></tr>
-<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4avc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4avc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4avc RCSB], [http://www.ebi.ac.uk/pdbsum/4avc PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4avc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4avc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4avc RCSB], [http://www.ebi.ac.uk/pdbsum/4avc PDBsum]</span></td></tr>
-<table>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/O05581_MYCTU O05581_MYCTU]] Catalyzes specifically the acetylation of the epsilon-amino group of a highly conserved lysine residue in acetyl-CoA synthetase (ACS). This acetylation results in the inactivation of ACS activity and could be important for mycobacteria to adjust to environmental changes.<ref>PMID:20507997</ref> <ref>PMID:21627103</ref> <ref>PMID:22773105</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
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 </StructureSection>
 [[Category: Mycobacterium tuberculosis]]
-[[Category: Alber, T.]]
+[[Category: Alber, T]]
-[[Category: Fortune, S M.]]
+[[Category: Fortune, S M]]
-[[Category: Lang, P T.]]
+[[Category: Lang, P T]]
-[[Category: Lee, H J.]]
+[[Category: Lee, H J]]
-[[Category: Sassetti, C M.]]
+[[Category: Sassetti, C M]]
 [[Category: Acetyltransferase]]
 [[Category: Allosteric regulation]]
 [[Category: Domain coupling]]
 [[Category: Transferase]]