1pus: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1pus]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PUS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PUS FirstGlance]. <br> | <table><tr><td colspan='2'>[[1pus]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PUS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PUS FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8OG:8-OXO-2-DEOXY-GUANOSINE-5-MONOPHOSPHATE'>8OG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8OG:8-OXO-2-DEOXY-GUANOSINE-5-MONOPHOSPHATE'>8OG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ppx|1ppx]], [[1mut|1mut]], [[1tum|1tum]], [[1pun|1pun]], [[1puq|1puq]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ppx|1ppx]], [[1mut|1mut]], [[1tum|1tum]], [[1pun|1pun]], [[1puq|1puq]]</td></tr> | ||
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MUTT,STRAIN: K12-I7023 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MUTT,STRAIN: K12-I7023 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pus OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pus RCSB], [http://www.ebi.ac.uk/pdbsum/1pus PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pus OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pus RCSB], [http://www.ebi.ac.uk/pdbsum/1pus PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/MUTT_ECOLI MUTT_ECOLI]] Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus leading to A.T to G.C transversions. MutT specifically degrades 8-oxo-dGTP to the monophosphate.<ref>PMID:1309939</ref> <ref>PMID:15850400</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Azurmendi, H F | [[Category: Azurmendi, H F]] | ||
[[Category: Massiah, M A | [[Category: Massiah, M A]] | ||
[[Category: Mildvan, A S | [[Category: Mildvan, A S]] | ||
[[Category: Saraswat, V | [[Category: Saraswat, V]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Mutator protein]] | [[Category: Mutator protein]] | ||
[[Category: Mutt pyrophosphohydrolase-metal-product complex]] | [[Category: Mutt pyrophosphohydrolase-metal-product complex]] | ||
[[Category: Nucleoside triphosphate pyrophosphohydrolase]] | [[Category: Nucleoside triphosphate pyrophosphohydrolase]] | ||