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==Crystal structure of the SH3 domain from IRSp53 (BAIAP2)== | |||
<StructureSection load='3rnj' size='340' side='right' caption='[[3rnj]], [[Resolution|resolution]] 1.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3rnj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RNJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RNJ FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EDT:{[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC+ACID'>EDT</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BAIAP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rnj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rnj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rnj RCSB], [http://www.ebi.ac.uk/pdbsum/3rnj PDBsum]</span></td></tr> | |||
== | </table> | ||
[[3rnj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RNJ OCA]. | == Function == | ||
[[http://www.uniprot.org/uniprot/BAIP2_HUMAN BAIP2_HUMAN]] Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.<ref>PMID:11130076</ref> <ref>PMID:11696321</ref> <ref>PMID:14752106</ref> <ref>PMID:19366662</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith, C H | [[Category: Arrowsmith, C H]] | ||
[[Category: Barilari, M | [[Category: Barilari, M]] | ||
[[Category: Bountra, C | [[Category: Bountra, C]] | ||
[[Category: Chaikuad, A | [[Category: Chaikuad, A]] | ||
[[Category: Delft, F von | [[Category: Delft, F von]] | ||
[[Category: Dente, L | [[Category: Dente, L]] | ||
[[Category: Edwards, A M]] | [[Category: Edwards, A M]] | ||
[[Category: Feller, S M | [[Category: Feller, S M]] | ||
[[Category: Filippakopoulos, P | [[Category: Filippakopoulos, P]] | ||
[[Category: Knapp, S | [[Category: Knapp, S]] | ||
[[Category: Muniz, J R.C | [[Category: Muniz, J R.C]] | ||
[[Category: Raynor, J | [[Category: Raynor, J]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Simister, P C | [[Category: Simister, P C]] | ||
[[Category: Tregubova, A | [[Category: Tregubova, A]] | ||
[[Category: Vollmar, M | [[Category: Vollmar, M]] | ||
[[Category: Weigelt, J | [[Category: Weigelt, J]] | ||
[[Category: Beta barrel]] | [[Category: Beta barrel]] | ||
[[Category: Proline-rich motif]] | [[Category: Proline-rich motif]] | ||
| Line 31: | Line 36: | ||
[[Category: Protein interaction domain]] | [[Category: Protein interaction domain]] | ||
[[Category: Sgc]] | [[Category: Sgc]] | ||