2gnc: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2gnc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GNC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GNC FirstGlance]. <br> | <table><tr><td colspan='2'>[[2gnc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GNC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GNC FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gnc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gnc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gnc RCSB], [http://www.ebi.ac.uk/pdbsum/2gnc PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gnc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gnc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gnc RCSB], [http://www.ebi.ac.uk/pdbsum/2gnc PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/SRGP1_MOUSE SRGP1_MOUSE]] GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42 (By similarity). | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Bartlam, M | [[Category: Bartlam, M]] | ||
[[Category: Gao, F | [[Category: Gao, F]] | ||
[[Category: Li, X | [[Category: Li, X]] | ||
[[Category: Liu, Y | [[Category: Liu, Y]] | ||
[[Category: Rao, Z | [[Category: Rao, Z]] | ||
[[Category: Wu, J Y | [[Category: Wu, J Y]] | ||
[[Category: Beta barrel]] | [[Category: Beta barrel]] | ||
[[Category: Signaling protein]] | [[Category: Signaling protein]] | ||