1yd9: Difference between revisions

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Revision as of 16:21, 20 March 2008

File:1yd9.gif

, resolution 1.6Å

Ligands:

Gene:

H2afy (Rattus norvegicus)

Coordinates:

save as pdb, mmCIF, xml

1.6A Crystal Structure of the Non-Histone Domain of the Histone Variant MacroH2A1.1.

OverviewOverview

macroH2A is an H2A variant with a highly unusual structural organization. It has a C-terminal domain connected to the N-terminal histone domain by a linker. Crystallographic and biochemical studies show that changes in the L1 loop in the histone fold region of macroH2A impact the structure and potentially the function of nucleosomes. The 1.6-A X-ray structure of the nonhistone region reveals an alpha/beta fold which has previously been found in a functionally diverse group of proteins. This region associates with histone deacetylases and affects the acetylation status of nucleosomes containing macroH2A. Thus, the unusual domain structure of macroH2A integrates independent functions that are instrumental in establishing a structurally and functionally unique chromatin domain.

About this StructureAbout this Structure

1YD9 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

ReferenceReference

Structural characterization of the histone variant macroH2A., Chakravarthy S, Gundimella SK, Caron C, Perche PY, Pehrson JR, Khochbin S, Luger K, Mol Cell Biol. 2005 Sep;25(17):7616-24. PMID:16107708

Page seeded by OCA on Thu Mar 20 15:21:21 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1yd9.gif|left|200px]]<br /><applet load="1yd9" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1yd9.gif|left|200px]]
-caption="1yd9, resolution 1.6&Aring;" />
-'''1.6A Crystal Structure of the Non-Histone Domain of the Histone Variant MacroH2A1.1.'''<br />
+ {{Structure
+|PDB= 1yd9 |SIZE=350|CAPTION= <scene name='initialview01'>1yd9</scene>, resolution 1.6&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=AU:GOLD ION'>AU</scene>
+|ACTIVITY=
+|GENE= H2afy ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
+}}
+'''1.6A Crystal Structure of the Non-Histone Domain of the Histone Variant MacroH2A1.1.'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-YD9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=AU:'>AU</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YD9 OCA].
+YD9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YD9 OCA].
 ==Reference==
-Structural characterization of the histone variant macroH2A., Chakravarthy S, Gundimella SK, Caron C, Perche PY, Pehrson JR, Khochbin S, Luger K, Mol Cell Biol. 2005 Sep;25(17):7616-24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16107708 16107708]
+Structural characterization of the histone variant macroH2A., Chakravarthy S, Gundimella SK, Caron C, Perche PY, Pehrson JR, Khochbin S, Luger K, Mol Cell Biol. 2005 Sep;25(17):7616-24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16107708 16107708]
 [[Category: Rattus norvegicus]]
 [[Category: Single protein]]
@@ Line 25: / Line 34: @@
 [[Category: macro-domain]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:04:10 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:21:21 2008''