4a33: Difference between revisions

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-[[Image:4a33.png|left|200px]]
+==CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND==
+<StructureSection load='4a33' size='340' side='right' caption='[[4a33]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4a33]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A33 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A33 FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=PS8:2,6-DICHLORO-4-(6-PIPERAZIN-1-YLPYRIDIN-3-YL)-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE'>PS8</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4a32|4a32]], [[4a2z|4a2z]], [[4a30|4a30]], [[2wsa|2wsa]], [[4a31|4a31]]</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a33 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a33 RCSB], [http://www.ebi.ac.uk/pdbsum/4a33 PDBsum]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/Q4Q5S8_LEIMA Q4Q5S8_LEIMA]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+N-Myristoyltransferase (NMT) represents a promising drug target for human African trypanosomiasis (HAT), which is caused by the parasitic protozoa Trypanosoma brucei. We report the optimization of a high throughput screening hit (1) to give a lead molecule DDD85646 (63), which has potent activity against the enzyme (IC(50) = 2 nM) and T. brucei (EC(50) = 2 nM) in culture. The compound has good oral pharmacokinetics and cures rodent models of peripheral HAT infection. This compound provides an excellent tool for validation of T. brucei NMT as a drug target for HAT as well as a valuable lead for further optimization.
-<!--
+Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors.,Brand S, Cleghorn LA, McElroy SP, Robinson DA, Smith VC, Hallyburton I, Harrison JR, Norcross NR, Spinks D, Bayliss T, Norval S, Stojanovski L, Torrie LS, Frearson JA, Brenk R, Fairlamb AH, Ferguson MA, Read KD, Wyatt PG, Gilbert IH J Med Chem. 2012 Jan 12;55(1):140-52. Epub 2011 Dec 7. PMID:22148754<ref>PMID:22148754</ref>
-The line below this paragraph, containing "STRUCTURE_4a33", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
-{{STRUCTURE_4a33|  PDB=4a33  |  SCENE=  }}
-===CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_22148754}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 22148754 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_22148754}}
-==About this Structure==
-[[4a33]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A33 OCA].
-==Reference==
-<ref group="xtra">PMID:022148754</ref><references group="xtra"/>
 [[Category: Glycylpeptide N-tetradecanoyltransferase]]
 [[Category: Leishmania major]]
-[[Category: Brand, S.]]
+[[Category: Brand, S]]
-[[Category: Brenk, R.]]
+[[Category: Brenk, R]]
-[[Category: Cleghorn, L A.T.]]
+[[Category: Cleghorn, L A.T]]
-[[Category: Fairlamb, A H.]]
+[[Category: Fairlamb, A H]]
-[[Category: Ferguson, M A.J.]]
+[[Category: Ferguson, M A.J]]
-[[Category: Frearson, J A.]]
+[[Category: Frearson, J A]]
-[[Category: Gilbert, I H.]]
+[[Category: Gilbert, I H]]
-[[Category: Hallyburton, I.]]
+[[Category: Hallyburton, I]]
-[[Category: Harrison, J R.]]
+[[Category: Harrison, J R]]
-[[Category: Mcelroy, S P.]]
+[[Category: Mcelroy, S P]]
-[[Category: Norcross, N R.]]
+[[Category: Norcross, N R]]
-[[Category: Norval, S.]]
+[[Category: Norval, S]]
-[[Category: Read, K D.]]
+[[Category: Read, K D]]
-[[Category: Robinson, D A.]]
+[[Category: Robinson, D A]]
-[[Category: Smith, V C.]]
+[[Category: Smith, V C]]
-[[Category: Spinks, D.]]
+[[Category: Spinks, D]]
-[[Category: Stojanovski, L.]]
+[[Category: Stojanovski, L]]
-[[Category: Torrie, L S.]]
+[[Category: Torrie, L S]]
-[[Category: Wyatt, P G.]]
+[[Category: Wyatt, P G]]
 [[Category: Drug discovery]]
 [[Category: Transferase]]