1y08: Difference between revisions
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'''Structure of the Streptococcal Endopeptidase IdeS, a Novel Cysteine Proteinase with Strict Specificity for IgG''' | {{Structure | ||
|PDB= 1y08 |SIZE=350|CAPTION= <scene name='initialview01'>1y08</scene>, resolution 1.93Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''Structure of the Streptococcal Endopeptidase IdeS, a Novel Cysteine Proteinase with Strict Specificity for IgG''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1Y08 is a [ | 1Y08 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y08 OCA]. | ||
==Reference== | ==Reference== | ||
Structure of the streptococcal endopeptidase IdeS, a cysteine proteinase with strict specificity for IgG., Wenig K, Chatwell L, von Pawel-Rammingen U, Bjorck L, Huber R, Sondermann P, Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17371-6. Epub 2004 Dec 1. PMID:[http:// | Structure of the streptococcal endopeptidase IdeS, a cysteine proteinase with strict specificity for IgG., Wenig K, Chatwell L, von Pawel-Rammingen U, Bjorck L, Huber R, Sondermann P, Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17371-6. Epub 2004 Dec 1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15574492 15574492] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Streptococcus pyogenes]] | [[Category: Streptococcus pyogenes]] | ||
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[[Category: SO4]] | [[Category: SO4]] | ||
[[Category: cysteine proteinase]] | [[Category: cysteine proteinase]] | ||
[[Category: papain-like fold with major | [[Category: papain-like fold with major insertion]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:16:52 2008'' | ||
Revision as of 16:16, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of the Streptococcal Endopeptidase IdeS, a Novel Cysteine Proteinase with Strict Specificity for IgG
OverviewOverview
Pathogenic bacteria have developed complex and diverse virulence mechanisms that weaken or disable the host immune defense system. IdeS (IgG-degrading enzyme of Streptococcus pyogenes) is a secreted cysteine endopeptidase from the human pathogen S. pyogenes with an extraordinarily high degree of substrate specificity, catalyzing a single proteolytic cleavage at the lower hinge of human IgG. This proteolytic degradation promotes inhibition of opsonophagocytosis and interferes with the killing of group A Streptococcus. We have determined the crystal structure of the catalytically inactive mutant IdeS-C94S by x-ray crystallography at 1.9-A resolution. Despite negligible sequence homology to known proteinases, the core of the structure resembles the canonical papain fold although with major insertions and a distinct substrate-binding site. Therefore IdeS belongs to a unique family within the CA clan of cysteine proteinases. Based on analogy with inhibitor complexes of papain-like proteinases, we propose a model for substrate binding by IdeS.
About this StructureAbout this Structure
1Y08 is a Single protein structure of sequence from Streptococcus pyogenes. Full crystallographic information is available from OCA.
ReferenceReference
Structure of the streptococcal endopeptidase IdeS, a cysteine proteinase with strict specificity for IgG., Wenig K, Chatwell L, von Pawel-Rammingen U, Bjorck L, Huber R, Sondermann P, Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17371-6. Epub 2004 Dec 1. PMID:15574492
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