1xud: Difference between revisions

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Revision as of 16:14, 20 March 2008

File:1xud.jpg

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Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor

OverviewOverview

The paradigm for matrix metalloprotease inhibition combines active site tailoring and catalytic zinc ligation. But, selectivity has been difficult. Now, Engel et al. present novel compounds, completely selective for MMP-13, with a unique binding mode.

About this StructureAbout this Structure

1XUD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Making a new turn in matrix metalloprotease inhibition., Wasserman ZR, Chem Biol. 2005 Feb;12(2):143-4. PMID:15734640

Page seeded by OCA on Thu Mar 20 15:14:38 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1xud.jpg|left|200px]]<br /><applet load="1xud" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1xud.jpg|left|200px]]
-caption="1xud, resolution 1.800&Aring;" />
-'''Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor'''<br />
+ {{Structure
+|PDB= 1xud |SIZE=350|CAPTION= <scene name='initialview01'>1xud</scene>, resolution 1.800&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=PB4:N,N'-BIS(4-FLUORO-3-METHYLBENZYL)PYRIMIDINE-4,6-DICARBOXAMIDE'>PB4</scene>
+|ACTIVITY=
+|GENE=
+}}
+'''Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-XUD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=PB4:'>PB4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XUD OCA].
+XUD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XUD OCA].
 ==Reference==
-Making a new turn in matrix metalloprotease inhibition., Wasserman ZR, Chem Biol. 2005 Feb;12(2):143-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15734640 15734640]
+Making a new turn in matrix metalloprotease inhibition., Wasserman ZR, Chem Biol. 2005 Feb;12(2):143-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15734640 15734640]
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
@@ Line 21: / Line 30: @@
 [[Category: non-zinc binding inhibitor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:58:44 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:14:38 2008''