2whr: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2whr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WHR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WHR FirstGlance]. <br> | <table><tr><td colspan='2'>[[2whr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WHR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WHR FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=K27:4-CARBAMOYL-1-(3-{4-[(E)-(HYDROXYIMINO)METHYL]PYRIDINIUM-1-YL}PROPYL)PYRIDINIUM'>K27</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P4G:1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE'>P4G</scene>, <scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=K27:4-CARBAMOYL-1-(3-{4-[(E)-(HYDROXYIMINO)METHYL]PYRIDINIUM-1-YL}PROPYL)PYRIDINIUM'>K27</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P4G:1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE'>P4G</scene>, <scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2jgh|2jgh]], [[1mah|1mah]], [[1maa|1maa]], [[2ha6|2ha6]], [[2c0q|2c0q]], [[2jgg|2jgg]], [[2jgl|2jgl]], [[1q84|1q84]], [[2jgm|2jgm]], [[2jge|2jge]], [[1q83|1q83]], [[1c2b|1c2b]], [[2ha3|2ha3]], [[2ha0|2ha0]], [[2jey|2jey]], [[2jgi|2jgi]], [[1n5r|1n5r]], [[2jgj|2jgj]], [[1j06|1j06]], [[2c0p|2c0p]], [[2jf0|2jf0]], [[2h9y|2h9y]], [[1n5m|1n5m]], [[2ha2|2ha2]], [[2ha5|2ha5]], [[2jez|2jez]], [[2jgk|2jgk]], [[1ku6|1ku6]], [[2ha4|2ha4]], [[1j07|1j07]], [[2ha7|2ha7]], [[2jgf|2jgf]], [[1c2o|1c2o]], [[2whq|2whq]], [[2whp|2whp]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2jgh|2jgh]], [[1mah|1mah]], [[1maa|1maa]], [[2ha6|2ha6]], [[2c0q|2c0q]], [[2jgg|2jgg]], [[2jgl|2jgl]], [[1q84|1q84]], [[2jgm|2jgm]], [[2jge|2jge]], [[1q83|1q83]], [[1c2b|1c2b]], [[2ha3|2ha3]], [[2ha0|2ha0]], [[2jey|2jey]], [[2jgi|2jgi]], [[1n5r|1n5r]], [[2jgj|2jgj]], [[1j06|1j06]], [[2c0p|2c0p]], [[2jf0|2jf0]], [[2h9y|2h9y]], [[1n5m|1n5m]], [[2ha2|2ha2]], [[2ha5|2ha5]], [[2jez|2jez]], [[2jgk|2jgk]], [[1ku6|1ku6]], [[2ha4|2ha4]], [[1j07|1j07]], [[2ha7|2ha7]], [[2jgf|2jgf]], [[1c2o|1c2o]], [[2whq|2whq]], [[2whp|2whp]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2whr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2whr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2whr RCSB], [http://www.ebi.ac.uk/pdbsum/2whr PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2whr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2whr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2whr RCSB], [http://www.ebi.ac.uk/pdbsum/2whr PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Acetylcholinesterase]] | [[Category: Acetylcholinesterase]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Artursson, E | [[Category: Artursson, E]] | ||
[[Category: Ekstrom, F | [[Category: Ekstrom, F]] | ||
[[Category: Hammarstrom, L G | [[Category: Hammarstrom, L G]] | ||
[[Category: Hornberg, A | [[Category: Hornberg, A]] | ||
[[Category: Pang, Y P | [[Category: Pang, Y P]] | ||
[[Category: Schneider, G | [[Category: Schneider, G]] | ||
[[Category: Cell junction]] | [[Category: Cell junction]] | ||
[[Category: Cell membrane]] | [[Category: Cell membrane]] | ||