1xqc: Difference between revisions

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[[Image:1xqc.gif|left|200px]]<br /><applet load="1xqc" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1xqc.gif|left|200px]]
caption="1xqc, resolution 2.05&Aring;" />
 
'''X-ray structure of ERalpha LBD bound to a tetrahydroisoquinoline SERM ligand at 2.05A resolution'''<br />
{{Structure
|PDB= 1xqc |SIZE=350|CAPTION= <scene name='initialview01'>1xqc</scene>, resolution 2.05&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=AEJ:(1S)-1-{4-[(9AR)-OCTAHYDRO-2H-PYRIDO[1,2-A]PYRAZIN-2-YL]PHENYL}-2-PHENYL-1,2,3,4-TETRAHYDROISOQUINOLIN-6-OL'>AEJ</scene>
|ACTIVITY=
|GENE=
}}
 
'''X-ray structure of ERalpha LBD bound to a tetrahydroisoquinoline SERM ligand at 2.05A resolution'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1XQC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=AEJ:'>AEJ</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XQC OCA].  
1XQC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XQC OCA].  


==Reference==
==Reference==
Selective estrogen receptor modulators with conformationally restricted side chains. Synthesis and structure-activity relationship of ERalpha-selective tetrahydroisoquinoline ligands., Renaud J, Bischoff SF, Buhl T, Floersheim P, Fournier B, Geiser M, Halleux C, Kallen J, Keller H, Ramage P, J Med Chem. 2005 Jan 27;48(2):364-79. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15658851 15658851]
Selective estrogen receptor modulators with conformationally restricted side chains. Synthesis and structure-activity relationship of ERalpha-selective tetrahydroisoquinoline ligands., Renaud J, Bischoff SF, Buhl T, Floersheim P, Fournier B, Geiser M, Halleux C, Kallen J, Keller H, Ramage P, J Med Chem. 2005 Jan 27;48(2):364-79. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15658851 15658851]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: nuclear hormone receptor]]
[[Category: nuclear hormone receptor]]


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