1lpi: Difference between revisions
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==Overview== | ==Overview== | ||
Experimental evidence of a cation-pi interaction between a sodium cation, (Na+) and the indole ring of residue Trp123 in a structure (2.0 A) of hen, egg-white lysozyme is presented. The geometry of the metal ion-pi, interaction observed in the protein structure (distance between the, aromatic plane and the cation approximately 4 A) is consistent with, geometries observed among small molecules crystal structures and quantum, chemistry ab initio calculations. The present crystal structure of, lysozyme provides unique structural information about the geometry of, binding of cations to pi systems in proteins. It shows that the metal, ion-pi interaction within proteins is not significantly different from, similar bindings found in small molecules and that it can be modeled by, theoretical . | Experimental evidence of a cation-pi interaction between a sodium cation, (Na+) and the indole ring of residue Trp123 in a structure (2.0 A) of hen, egg-white lysozyme is presented. The geometry of the metal ion-pi, interaction observed in the protein structure (distance between the, aromatic plane and the cation approximately 4 A) is consistent with, geometries observed among small molecules crystal structures and quantum, chemistry ab initio calculations. The present crystal structure of, lysozyme provides unique structural information about the geometry of, binding of cations to pi systems in proteins. It shows that the metal, ion-pi interaction within proteins is not significantly different from, similar bindings found in small molecules and that it can be modeled by, theoretical methods. | ||
==About this Structure== | ==About this Structure== | ||
1LPI is a | 1LPI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] with NA as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] Structure known Active Site: PON. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1LPI OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: o-glycosyl]] | [[Category: o-glycosyl]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 13:07:21 2007'' | ||