2adu: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2adu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ADU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ADU FirstGlance]. <br> | <table><tr><td colspan='2'>[[2adu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ADU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ADU FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=R20:4-(3-METHYLPHENYL)-1H-1,2,3-TRIAZOLE'>R20</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=R20:4-(3-METHYLPHENYL)-1H-1,2,3-TRIAZOLE'>R20</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">METAP2, MNPEP, P67EIF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">METAP2, MNPEP, P67EIF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18] </span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2adu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2adu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2adu RCSB], [http://www.ebi.ac.uk/pdbsum/2adu PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2adu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2adu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2adu RCSB], [http://www.ebi.ac.uk/pdbsum/2adu PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/AMPM2_HUMAN AMPM2_HUMAN]] Removes the N-terminal methionine from nascent proteins. The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.<ref>PMID:2511207</ref> <ref>PMID:20521764</ref> <ref>PMID:14534293</ref> <ref>PMID:17636946</ref> Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.<ref>PMID:2511207</ref> <ref>PMID:20521764</ref> <ref>PMID:14534293</ref> <ref>PMID:17636946</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Methionyl aminopeptidase]] | [[Category: Methionyl aminopeptidase]] | ||
[[Category: Chen, W | [[Category: Chen, W]] | ||
[[Category: Fisher, P W | [[Category: Fisher, P W]] | ||
[[Category: Hansbury, M J | [[Category: Hansbury, M J]] | ||
[[Category: Ho, T F | [[Category: Ho, T F]] | ||
[[Category: Hofmann, G A | [[Category: Hofmann, G A]] | ||
[[Category: Janson, C A | [[Category: Janson, C A]] | ||
[[Category: Johanson, K O | [[Category: Johanson, K O]] | ||
[[Category: Johnson, R K | [[Category: Johnson, R K]] | ||
[[Category: Kallander, L S | [[Category: Kallander, L S]] | ||
[[Category: Kirkpatrick, R B | [[Category: Kirkpatrick, R B]] | ||
[[Category: Lu, Q | [[Category: Lu, Q]] | ||
[[Category: Mattern, M R | [[Category: Mattern, M R]] | ||
[[Category: Meek, T D | [[Category: Meek, T D]] | ||
[[Category: Ryan, M D | [[Category: Ryan, M D]] | ||
[[Category: Schulz-Pritchard, C K | [[Category: Schulz-Pritchard, C K]] | ||
[[Category: Smith, W W | [[Category: Smith, W W]] | ||
[[Category: Tew, D | [[Category: Tew, D]] | ||
[[Category: Thompson, S K | [[Category: Thompson, S K]] | ||
[[Category: Tomaszek, T | [[Category: Tomaszek, T]] | ||
[[Category: Veber, D F | [[Category: Veber, D F]] | ||
[[Category: Ward, K W | [[Category: Ward, K W]] | ||
[[Category: Winkler, J D | [[Category: Winkler, J D]] | ||
[[Category: Yang, G | [[Category: Yang, G]] | ||
[[Category: Zhang, G F | [[Category: Zhang, G F]] | ||
[[Category: Aminopeptidase]] | [[Category: Aminopeptidase]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Metal binding]] | [[Category: Metal binding]] | ||
[[Category: Protease]] | [[Category: Protease]] | ||