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==Crystal structure of the R54G mutant of putrescine transcarbamylase from Enterococcus faecalis bound to a curing guanidinium ion== | |||
<StructureSection load='4am8' size='340' side='right' caption='[[4am8]], [[Resolution|resolution]] 1.99Å' scene=''> | |||
== Structural highlights == | |||
== | <table><tr><td colspan='2'>[[4am8]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AM8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AM8 FirstGlance]. <br> | ||
[[ | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAI:GUANIDINE'>GAI</scene>, <scene name='pdbligand=GLN:GLUTAMINE'>GLN</scene>, <scene name='pdbligand=ILE:ISOLEUCINE'>ILE</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PAO:N-(PHOSPHONOACETYL)-L-ORNITHINE'>PAO</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4a8h|4a8h]], [[4a8p|4a8p]], [[4a8t|4a8t]]</td></tr> | |||
== | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Putrescine_carbamoyltransferase Putrescine carbamoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.3.6 2.1.3.6] </span></td></tr> | ||
[[4am8]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AM8 OCA]. | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4am8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4am8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4am8 RCSB], [http://www.ebi.ac.uk/pdbsum/4am8 PDBsum]</span></td></tr> | ||
</table> | |||
== | == Function == | ||
< | [[http://www.uniprot.org/uniprot/PTC_ENTFA PTC_ENTFA]] Catalyzes the phosphorolysis of N-carbamoylputrescine to form carbamoyl phosphate and putrescine. Is involved in the degradation pathway of the polyamine agmatine. Also has weak activity with ornithine and cadaverine.<ref>PMID:4621632</ref> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Enterococcus faecalis]] | [[Category: Enterococcus faecalis]] | ||
[[Category: Putrescine carbamoyltransferase]] | [[Category: Putrescine carbamoyltransferase]] | ||
[[Category: Polo, L M | [[Category: Polo, L M]] | ||
[[Category: Rubio, V | [[Category: Rubio, V]] | ||
[[Category: Agmatine deiminase route]] | [[Category: Agmatine deiminase route]] | ||
[[Category: Arginine deiminase]] | [[Category: Arginine deiminase]] | ||
Revision as of 17:05, 24 December 2014
Crystal structure of the R54G mutant of putrescine transcarbamylase from Enterococcus faecalis bound to a curing guanidinium ionCrystal structure of the R54G mutant of putrescine transcarbamylase from Enterococcus faecalis bound to a curing guanidinium ion
Structural highlights
Function[PTC_ENTFA] Catalyzes the phosphorolysis of N-carbamoylputrescine to form carbamoyl phosphate and putrescine. Is involved in the degradation pathway of the polyamine agmatine. Also has weak activity with ornithine and cadaverine.[1] References |
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