1bhd: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bhd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bhd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bhd RCSB], [http://www.ebi.ac.uk/pdbsum/1bhd PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bhd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bhd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bhd RCSB], [http://www.ebi.ac.uk/pdbsum/1bhd PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/UTRO_HUMAN UTRO_HUMAN]] May play a role in anchoring the cytoskeleton to the plasma membrane (By similarity). | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 16:53, 24 December 2014
SECOND CALPONIN HOMOLOGY DOMAIN FROM UTROPHINSECOND CALPONIN HOMOLOGY DOMAIN FROM UTROPHIN
Structural highlights
Function[UTRO_HUMAN] May play a role in anchoring the cytoskeleton to the plasma membrane (By similarity). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedUtrophin is a close homologue of dystrophin, the protein defective in Duchenne muscular dystrophy. Like dystrophin, it is composed of three regions: an N-terminal region that binds actin filaments, a large central region with triple coiled-coil repeats, and a C-terminal region that interacts with components in the dystroglycan protein complex at the plasma membrane. The N-terminal actin-binding region consists of two calponin homology domains and is related to the actin-binding domains of a superfamily of proteins including alpha-actinin, spectrin and fimbrin. Here, we present the 2.0 A structure of the second calponin homology domain of utrophin solved by X-ray crystallography, and compare it to the other calponin homology domains previously determined from spectrin and fimbrin. The 2.0 A structure of the second calponin homology domain from the actin-binding region of the dystrophin homologue utrophin.,Keep NH, Norwood FL, Moores CA, Winder SJ, Kendrick-Jones J J Mol Biol. 1999 Jan 22;285(3):1257-64. PMID:9887274[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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