1wlh: Difference between revisions
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'''Molecular structure of the rod domain of Dictyostelium filamin''' | {{Structure | ||
|PDB= 1wlh |SIZE=350|CAPTION= <scene name='initialview01'>1wlh</scene>, resolution 2.80Å | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= | |||
|GENE= ABPC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=44689 Dictyostelium discoideum]) | |||
}} | |||
'''Molecular structure of the rod domain of Dictyostelium filamin''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1WLH is a [ | 1WLH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WLH OCA]. | ||
==Reference== | ==Reference== | ||
Molecular structure of the rod domain of dictyostelium filamin., Popowicz GM, Muller R, Noegel AA, Schleicher M, Huber R, Holak TA, J Mol Biol. 2004 Oct 1;342(5):1637-46. PMID:[http:// | Molecular structure of the rod domain of dictyostelium filamin., Popowicz GM, Muller R, Noegel AA, Schleicher M, Huber R, Holak TA, J Mol Biol. 2004 Oct 1;342(5):1637-46. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15364587 15364587] | ||
[[Category: Dictyostelium discoideum]] | [[Category: Dictyostelium discoideum]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: rod domain]] | [[Category: rod domain]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:58:30 2008'' | ||
Revision as of 15:58, 20 March 2008
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| , resolution 2.80Å | |||||||
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| Gene: | ABPC (Dictyostelium discoideum) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Molecular structure of the rod domain of Dictyostelium filamin
OverviewOverview
Dictyostelium discoideum filamin (ddFLN) is a two-chain F-actin crosslinking protein with an N-terminal actin-binding domain and a rod domain constructed from six tandem repeats of a 100 residue motif that has an immunoglobulin (Ig) fold. We report the 2.8 A resolution crystal structure of a homodimer of rod repeats 4, 5 and 6. The two chains are arranged in an antiparallel fashion and form an elongated element, which is shortened, however, compared to a fully extended, linear configuration because the long axis of each Ig domain is arranged at an angle to the long axis of the rod. Same arrangement of repeats should also be present in the rod domain of human FLNa, much longer than Dictyostelium FLN, which forms an extended structure able to crosslink F-actin chains over distances of more than 1000 A.
About this StructureAbout this Structure
1WLH is a Single protein structure of sequence from Dictyostelium discoideum. Full crystallographic information is available from OCA.
ReferenceReference
Molecular structure of the rod domain of dictyostelium filamin., Popowicz GM, Muller R, Noegel AA, Schleicher M, Huber R, Holak TA, J Mol Biol. 2004 Oct 1;342(5):1637-46. PMID:15364587
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