4tk1: Difference between revisions

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'''Unreleased structure'''
==Geph E in complex with a GABA receptor alpha3 subunit derived peptide in space group P21212==
 
<StructureSection load='4tk1' size='340' side='right' caption='[[4tk1]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
The entry 4tk1 is ON HOLD until Paper Publication
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4tk1]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TK1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TK1 FirstGlance]. <br>
Authors: Kasaragod, V.B., Maric, H.M., Schindelin, H.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
 
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4tk2|4tk2]], [[4tk3|4tk3]], [[4tk4|4tk4]]</td></tr>
Description:
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tk1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tk1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tk1 RCSB], [http://www.ebi.ac.uk/pdbsum/4tk1 PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/GEPH_RAT GEPH_RAT]] Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.<ref>PMID:8264797</ref> <ref>PMID:9990024</ref> [[http://www.uniprot.org/uniprot/GBRA3_RAT GBRA3_RAT]] GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Kasaragod, V B]]
[[Category: Maric, H M]]
[[Category: Schindelin, H]]
[[Category: Biosynthetic protein]]
[[Category: Molybdenum co factor biosynthesis]]
[[Category: Neurotransmitter receptor anchoring]]
[[Category: Scaffolding protein]]
[[Category: Structural protein]]

Revision as of 14:11, 24 December 2014

Geph E in complex with a GABA receptor alpha3 subunit derived peptide in space group P21212Geph E in complex with a GABA receptor alpha3 subunit derived peptide in space group P21212

Structural highlights

4tk1 is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[GEPH_RAT] Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.[1] [2] [GBRA3_RAT] GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

References

  1. ↑ Kirsch J, Wolters I, Triller A, Betz H. Gephyrin antisense oligonucleotides prevent glycine receptor clustering in spinal neurons. Nature. 1993 Dec 23-30;366(6457):745-8. PMID:8264797 doi:http://dx.doi.org/10.1038/366745a0
  2. ↑ Stallmeyer B, Schwarz G, Schulze J, Nerlich A, Reiss J, Kirsch J, Mendel RR. The neurotransmitter receptor-anchoring protein gephyrin reconstitutes molybdenum cofactor biosynthesis in bacteria, plants, and mammalian cells. Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1333-8. PMID:9990024

4tk1, resolution 2.70Å

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