4l56: Difference between revisions

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'''Unreleased structure'''
==tRNA guanine transglycosylase H333D mutant apo structure==
 
<StructureSection load='4l56' size='340' side='right' caption='[[4l56]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
The entry 4l56 is ON HOLD  until Paper Publication
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4l56]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L56 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L56 FirstGlance]. <br>
Authors: Nguyen, T.X.P., Heine, A., Klebe, G.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1pud|1pud]], [[3bld|3bld]], [[3unt|3unt]], [[4kwo|4kwo]]</td></tr>
Description: tRNA guanine transglycosylase H333D mutant apo structure
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA-guanine(34)_transglycosylase tRNA-guanine(34) transglycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.29 2.4.2.29] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l56 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l56 RCSB], [http://www.ebi.ac.uk/pdbsum/4l56 PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO]] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]
__TOC__
</StructureSection>
[[Category: Heine, A]]
[[Category: Klebe, G]]
[[Category: Nguyen, T X.P]]
[[Category: Dimer interface]]
[[Category: Glycosyltransferase]]
[[Category: Guanine binding]]
[[Category: Metal-binding]]
[[Category: Queuosine]]
[[Category: Tgt]]
[[Category: Transferase]]
[[Category: Trna]]
[[Category: Trna processing]]
[[Category: Zinc binding]]

Revision as of 11:12, 24 December 2014

tRNA guanine transglycosylase H333D mutant apo structuretRNA guanine transglycosylase H333D mutant apo structure

Structural highlights

4l56 is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Activity:tRNA-guanine(34) transglycosylase, with EC number 2.4.2.29
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[TGT_ZYMMO] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]

4l56, resolution 1.70Å

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OCA
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