3fk2: Difference between revisions

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fk2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fk2 RCSB], [http://www.ebi.ac.uk/pdbsum/3fk2 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fk2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fk2 RCSB], [http://www.ebi.ac.uk/pdbsum/3fk2 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/GRLF1_HUMAN GRLF1_HUMAN]] Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'. May participate in the regulation of retinal development and degeneration. May transduce signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP). May also act as a tumor suppressor.<ref>PMID:1894621</ref> <ref>PMID:11054565</ref> 
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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== References ==
<references/>
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__TOC__
</StructureSection>
</StructureSection>

Revision as of 10:58, 24 December 2014

Crystal structure of the RhoGAP domain of human glucocorticoid receptor DNA-binding factor 1Crystal structure of the RhoGAP domain of human glucocorticoid receptor DNA-binding factor 1

Structural highlights

3fk2 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Gene:GRLF1, GRF1, KIAA1722 (Homo sapiens)
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[GRLF1_HUMAN] Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'. May participate in the regulation of retinal development and degeneration. May transduce signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP). May also act as a tumor suppressor.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ LeClerc S, Palaniswami R, Xie BX, Govindan MV. Molecular cloning and characterization of a factor that binds the human glucocorticoid receptor gene and represses its expression. J Biol Chem. 1991 Sep 15;266(26):17333-40. PMID:1894621
  2. ↑ Tikoo A, Czekay S, Viars C, White S, Heath JK, Arden K, Maruta H. p190-A, a human tumor suppressor gene, maps to the chromosomal region 19q13.3 that is reportedly deleted in some gliomas. Gene. 2000 Oct 17;257(1):23-31. PMID:11054565

3fk2, resolution 2.80Å

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