1vid: Difference between revisions

← Older edit Newer edit →

Revision as of 15:46, 20 March 2008

File:1vid.gif

, resolution 2.Å

Ligands:

, and

Activity:

Catechol O-methyltransferase, with EC number 2.1.1.6

Coordinates:

save as pdb, mmCIF, xml

CATECHOL O-METHYLTRANSFERASE

OverviewOverview

Catechol O-methyltransferase (COMT, EC 2.1.1.6) is important in the central nervous system because it metabolizes catecholamine neurotransmitters such as dopamine. The enzyme catalyses the transfer of the methyl group from S-adenosyl-L-methionine (AdoMet) to one hydroxyl group of catechols. COMT also inactivates catechol-type compounds such as L-DOPA. With selective inhibitors of COMT in combination with L-DOPA, a new principle has been realized in the therapy of Parkinson's disease. Here we solve the atomic structure of COMT to 2.0 A resolution, which provides new insights into the mechanism of the methyl transfer reaction. The co-enzyme-binding domain is strikingly similar to that of an AdoMet-dependent DNA methylase, indicating that all AdoMet methylases may have a common structure.

About this StructureAbout this Structure

1VID is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of catechol O-methyltransferase., Vidgren J, Svensson LA, Liljas A, Nature. 1994 Mar 24;368(6469):354-8. PMID:8127373

Page seeded by OCA on Thu Mar 20 14:46:02 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1vid.gif|left|200px]]<br /><applet load="1vid" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1vid.gif|left|200px]]
-caption="1vid, resolution 2.&Aring;" />
-'''CATECHOL O-METHYLTRANSFERASE'''<br />
+ {{Structure
+|PDB= 1vid |SIZE=350|CAPTION= <scene name='initialview01'>1vid</scene>, resolution 2.&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene> and <scene name='pdbligand=DNC:3,5-DINITROCATECHOL'>DNC</scene>
+|ACTIVITY= [http://en.wikipedia.org/wiki/Catechol_O-methyltransferase Catechol O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.6 2.1.1.6]
+|GENE=
+}}
+'''CATECHOL O-METHYLTRANSFERASE'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-VID is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=SAM:'>SAM</scene> and <scene name='pdbligand=DNC:'>DNC</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Catechol_O-methyltransferase Catechol O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.6 2.1.1.6] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VID OCA].
+VID is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VID OCA].
 ==Reference==
-Crystal structure of catechol O-methyltransferase., Vidgren J, Svensson LA, Liljas A, Nature. 1994 Mar 24;368(6469):354-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8127373 8127373]
+Crystal structure of catechol O-methyltransferase., Vidgren J, Svensson LA, Liljas A, Nature. 1994 Mar 24;368(6469):354-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8127373 8127373]
 [[Category: Catechol O-methyltransferase]]
 [[Category: Rattus norvegicus]]
@@ Line 24: / Line 33: @@
 [[Category: transferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:35:37 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:46:02 2008''