1eiw: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1eiw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EIW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EIW FirstGlance]. <br> | <table><tr><td colspan='2'>[[1eiw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EIW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EIW FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1eiw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eiw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1eiw RCSB], [http://www.ebi.ac.uk/pdbsum/1eiw PDBsum], [http://www.topsan.org/Proteins/NESGC/1eiw TOPSAN]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1eiw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eiw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1eiw RCSB], [http://www.ebi.ac.uk/pdbsum/1eiw PDBsum], [http://www.topsan.org/Proteins/NESGC/1eiw TOPSAN]</span></td></tr> | ||
<table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Methanothermobacter thermautotrophicus]] | [[Category: Methanothermobacter thermautotrophicus]] | ||
[[Category: Arrowsmith, C H | [[Category: Arrowsmith, C H]] | ||
[[Category: Cort, J R | [[Category: Cort, J R]] | ||
[[Category: Kennedy, M A | [[Category: Kennedy, M A]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Chey-like fold]] | [[Category: Chey-like fold]] | ||
[[Category: Flavodoxin-like fold]] | [[Category: Flavodoxin-like fold]] | ||
[[Category: Nesg]] | [[Category: Nesg]] | ||
[[Category: Parallel beta sheet]] | [[Category: Parallel beta sheet]] | ||
[[Category: Protein structure initiative | [[Category: PSI, Protein structure initiative]] | ||
Revision as of 03:15, 23 December 2014
Solution structure of hypothetical protein MTH538 from Methanobacterium thermoautotrophicumSolution structure of hypothetical protein MTH538 from Methanobacterium thermoautotrophicum
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedThe structure of MTH538, a previously uncharacterized hypothetical protein from Methanobacterium thermoautotrophicum, has been determined by NMR spectroscopy. MTH538 is one of numerous structural genomics targets selected in a genome-wide survey of uncharacterized sequences from this organism. MTH538 is a so-called singleton, a sequence not closely related to any other (known) sequences. The structure of MTH538 closely resembles the known structures of receiver domains from two component response regulator systems, such as CheY, and is similar to the structures of flavodoxins and GTP-binding proteins. Tests on MTH538 for characteristic activities of CheY and flavodoxin were negative. MTH538 did not become phosphorylated in the presence of acetyl phosphate and Mg(2+), although it appeared to bind Mg(2+). MTH538 also did not bind flavin mononucleotide (FMN) or coenzyme F(420). Nevertheless, sequence and structure parallels between MTH538/CheY and two families of ATPase/phosphatase proteins suggest that MTH538 may have a role in a phosphorylation-independent two-component response regulator system. Structure-based functional classification of hypothetical protein MTH538 from Methanobacterium thermoautotrophicum.,Cort JR, Yee A, Edwards AM, Arrowsmith CH, Kennedy MA J Mol Biol. 2000 Sep 8;302(1):189-203. PMID:10964569[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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