1h8t: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1h8t]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_echovirus_11 Human echovirus 11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H8T FirstGlance]. <br> | <table><tr><td colspan='2'>[[1h8t]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_echovirus_11 Human echovirus 11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H8T FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DOA:12-AMINO-DODECANOIC+ACID'>DOA</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DOA:12-AMINO-DODECANOIC+ACID'>DOA</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h8t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h8t RCSB], [http://www.ebi.ac.uk/pdbsum/1h8t PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h8t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h8t RCSB], [http://www.ebi.ac.uk/pdbsum/1h8t PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human echovirus 11]] | [[Category: Human echovirus 11]] | ||
[[Category: Brown, T D.K | [[Category: Brown, T D.K]] | ||
[[Category: Harley, C | [[Category: Harley, C]] | ||
[[Category: Lea, S M | [[Category: Lea, S M]] | ||
[[Category: Mckee, T | [[Category: Mckee, T]] | ||
[[Category: Stuart, A | [[Category: Stuart, A]] | ||
[[Category: Stuart, D I | [[Category: Stuart, D I]] | ||
[[Category: Williams, P A | [[Category: Williams, P A]] | ||
[[Category: Echovirus]] | [[Category: Echovirus]] | ||
[[Category: Echovirus coat protein]] | [[Category: Echovirus coat protein]] | ||
[[Category: Icosahedral virus]] | [[Category: Icosahedral virus]] | ||
[[Category: Virus]] | [[Category: Virus]] | ||
Revision as of 01:42, 23 December 2014
Echovirus 11Echovirus 11
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedWe have used X-ray crystallography to determine the structure of a decay accelerating factor (DAF)-binding, clinic-derived isolate of echovirus 11 (EV11-207). The structures of the capsid proteins closely resemble those of capsid proteins of other picornaviruses. The structure allows us to interpret a series of amino acid changes produced by passaging EV11-207 in different cell lines as highlighting the locations of multiple receptor-binding sites on the virion surface. We suggest that a DAF-binding site is located at the fivefold axes of the virion, while the binding site for a distinct but as yet unidentified receptor is located within the canyon surrounding the virion fivefold axes. Determination of the structure of a decay accelerating factor-binding clinical isolate of echovirus 11 allows mapping of mutants with altered receptor requirements for infection.,Stuart AD, McKee TA, Williams PA, Harley C, Shen S, Stuart DI, Brown TD, Lea SM J Virol. 2002 Aug;76(15):7694-704. PMID:12097583[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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