1gxj: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1gxj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GXJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GXJ FirstGlance]. <br> | <table><tr><td colspan='2'>[[1gxj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GXJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GXJ FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1e69|1e69]], [[1gxk|1gxk]], [[1gxl|1gxl]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1e69|1e69]], [[1gxk|1gxk]], [[1gxl|1gxl]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gxj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gxj RCSB], [http://www.ebi.ac.uk/pdbsum/1gxj PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gxj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gxj RCSB], [http://www.ebi.ac.uk/pdbsum/1gxj PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Thermotoga maritima]] | [[Category: Thermotoga maritima]] | ||
[[Category: Haering, C | [[Category: Haering, C]] | ||
[[Category: Lowe, J | [[Category: Lowe, J]] | ||
[[Category: Nasmyth, K | [[Category: Nasmyth, K]] | ||
[[Category: Anti parallel coiled coil]] | [[Category: Anti parallel coiled coil]] | ||
[[Category: Chromosome segregation]] | [[Category: Chromosome segregation]] | ||
[[Category: Smc dimerisation domain]] | [[Category: Smc dimerisation domain]] | ||
[[Category: Smc protein]] | [[Category: Smc protein]] | ||
Revision as of 01:28, 23 December 2014
SMC HINGE DOMAIN FROM T. MARITIMA W/O COILED COILSMC HINGE DOMAIN FROM T. MARITIMA W/O COILED COIL
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedSister chromatids are held together by the multisubunit cohesin complex, which contains two SMC (Smc1 and Smc3) and two non-SMC (Scc1 and Scc3) proteins. The crystal structure of a bacterial SMC "hinge" region along with EM studies and biochemical experiments on yeast Smc1 and Smc3 proteins show that SMC protamers fold up individually into rod-shaped molecules. A 45 nm long intramolecular coiled coil separates the hinge region from the ATPase-containing "head" domain. Smc1 and Smc3 bind to each other via heterotypic interactions between their hinges to form a V-shaped heterodimer. The two heads of the V-shaped dimer are connected by different ends of the cleavable Scc1 subunit. Cohesin therefore forms a large proteinaceous loop within which sister chromatids might be entrapped after DNA replication. Molecular architecture of SMC proteins and the yeast cohesin complex.,Haering CH, Lowe J, Hochwagen A, Nasmyth K Mol Cell. 2002 Apr;9(4):773-88. PMID:11983169[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References |
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