1v39: Difference between revisions

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Revision as of 15:40, 20 March 2008

File:1v39.gif

, resolution 1.8Å

Ligands:

and

Activity:

Polynucleotide adenylyltransferase, with EC number 2.7.7.19

Coordinates:

save as pdb, mmCIF, xml

DC26 MUTANT OF VACCINIA VIRUS PROTEIN VP39 IN COMPLEX WITH S-ADENOSYLHOMOCYSTEINE AND M7G(5')PPPG

OverviewOverview

The specific binding of N7-methylguanine cap analogues to the RNA methyltransferase VP39 was observed through X-ray crystallography, providing a prototypical structure for a complex between a protein and an mRNA 5' cap.

About this StructureAbout this Structure

1V39 is a Single protein structure of sequence from Vaccinia virus. Full crystallographic information is available from OCA.

ReferenceReference

Specific protein recognition of an mRNA cap through its alkylated base., Hodel AE, Gershon PD, Shi X, Wang SM, Quiocho FA, Nat Struct Biol. 1997 May;4(5):350-4. PMID:9145102

Page seeded by OCA on Thu Mar 20 14:40:15 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1v39.gif|left|200px]]<br /><applet load="1v39" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1v39.gif|left|200px]]
-caption="1v39, resolution 1.8&Aring;" />
-'''DC26 MUTANT OF VACCINIA VIRUS PROTEIN VP39 IN COMPLEX WITH S-ADENOSYLHOMOCYSTEINE AND M7G(5')PPPG'''<br />
+ {{Structure
+|PDB= 1v39 |SIZE=350|CAPTION= <scene name='initialview01'>1v39</scene>, resolution 1.8&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene> and <scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE'>M7G</scene>
+|ACTIVITY= [http://en.wikipedia.org/wiki/Polynucleotide_adenylyltransferase Polynucleotide adenylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.19 2.7.7.19]
+|GENE=
+}}
+'''DC26 MUTANT OF VACCINIA VIRUS PROTEIN VP39 IN COMPLEX WITH S-ADENOSYLHOMOCYSTEINE AND M7G(5')PPPG'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-V39 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus] with <scene name='pdbligand=SAH:'>SAH</scene> and <scene name='pdbligand=M7G:'>M7G</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Polynucleotide_adenylyltransferase Polynucleotide adenylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.19 2.7.7.19] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V39 OCA].
+V39 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V39 OCA].
 ==Reference==
-Specific protein recognition of an mRNA cap through its alkylated base., Hodel AE, Gershon PD, Shi X, Wang SM, Quiocho FA, Nat Struct Biol. 1997 May;4(5):350-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9145102 9145102]
+Specific protein recognition of an mRNA cap through its alkylated base., Hodel AE, Gershon PD, Shi X, Wang SM, Quiocho FA, Nat Struct Biol. 1997 May;4(5):350-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9145102 9145102]
 [[Category: Polynucleotide adenylyltransferase]]
 [[Category: Single protein]]
@@ Line 26: / Line 35: @@
 [[Category: vaccinia]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:31:03 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:40:15 2008''