1uuj: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1uuj.gif|left|200px]] | [[Image:1uuj.gif|left|200px]] | ||
'''N-TERMINAL DOMAIN OF LISSENCEPHALY-1 PROTEIN (LIS-1)''' | {{Structure | ||
|PDB= 1uuj |SIZE=350|CAPTION= <scene name='initialview01'>1uuj</scene>, resolution 1.75Å | |||
|SITE= <scene name='pdbsite=AC1:Bez+Binding+Site+For+Chain+C'>AC1</scene> | |||
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene> and <scene name='pdbligand=BEZ:BENZOIC ACID'>BEZ</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''N-TERMINAL DOMAIN OF LISSENCEPHALY-1 PROTEIN (LIS-1)''' | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
1UUJ is a [ | 1UUJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UUJ OCA]. | ||
==Reference== | ==Reference== | ||
The structure of the N-terminal domain of the product of the lissencephaly gene Lis1 and its functional implications., Kim MH, Cooper DR, Oleksy A, Devedjiev Y, Derewenda U, Reiner O, Otlewski J, Derewenda ZS, Structure. 2004 Jun;12(6):987-98. PMID:[http:// | The structure of the N-terminal domain of the product of the lissencephaly gene Lis1 and its functional implications., Kim MH, Cooper DR, Oleksy A, Devedjiev Y, Derewenda U, Reiner O, Otlewski J, Derewenda ZS, Structure. 2004 Jun;12(6):987-98. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15274919 15274919] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 28: | Line 37: | ||
[[Category: platelet-activating factor acetylhydrolase]] | [[Category: platelet-activating factor acetylhydrolase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:36:57 2008'' | ||
Revision as of 15:36, 20 March 2008
| |||||||
| , resolution 1.75Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | |||||||
| Ligands: | , and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
N-TERMINAL DOMAIN OF LISSENCEPHALY-1 PROTEIN (LIS-1)
OverviewOverview
Mutations in the Lis1 gene result in lissencephaly (smooth brain), a debilitating developmental syndrome caused by the impaired ability of postmitotic neurons to migrate to their correct destination in the cerebral cortex. Sequence similarities suggest that the LIS1 protein contains a C-terminal seven-blade beta-propeller domain, while the structure of the N-terminal fragment includes the LisH (Lis-homology) motif, a pattern found in over 100 eukaryotic proteins with a hitherto unknown function. We present the 1.75 A resolution crystal structure of the N-terminal domain of mouse LIS1, and we show that the LisH motif is a novel, thermodynamically very stable dimerization domain. The structure explains the molecular basis of a low severity form of lissencephaly.
About this StructureAbout this Structure
1UUJ is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
ReferenceReference
The structure of the N-terminal domain of the product of the lissencephaly gene Lis1 and its functional implications., Kim MH, Cooper DR, Oleksy A, Devedjiev Y, Derewenda U, Reiner O, Otlewski J, Derewenda ZS, Structure. 2004 Jun;12(6):987-98. PMID:15274919
Page seeded by OCA on Thu Mar 20 14:36:57 2008