1dzl: Difference between revisions
No edit summary |
No edit summary |
||
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1dzl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_16 Human papillomavirus type 16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DZL FirstGlance]. <br> | <table><tr><td colspan='2'>[[1dzl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_16 Human papillomavirus type 16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DZL FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dzl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dzl RCSB], [http://www.ebi.ac.uk/pdbsum/1dzl PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dzl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1dzl RCSB], [http://www.ebi.ac.uk/pdbsum/1dzl PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 31: | Line 31: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human papillomavirus type 16]] | [[Category: Human papillomavirus type 16]] | ||
[[Category: Chen, X J | [[Category: Chen, X J]] | ||
[[Category: Garcea, B | [[Category: Garcea, B]] | ||
[[Category: Goldberge, I | [[Category: Goldberge, I]] | ||
[[Category: Harrison, S C | [[Category: Harrison, S C]] | ||
[[Category: Icosahedral]] | [[Category: Icosahedral]] | ||
[[Category: Virus]] | [[Category: Virus]] | ||
Revision as of 22:56, 22 December 2014
L1 PROTEIN OF HUMAN PAPILLOMAVIRUS 16L1 PROTEIN OF HUMAN PAPILLOMAVIRUS 16
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedThe papillomavirus major late protein, L1, forms the pentameric assembly unit of the viral shell. Recombinant HPV16 L1 pentamers assemble in vitro into capsid-like structures, and truncation of ten N-terminal residues leads to a homogeneous preparation of 12-pentamer, icosahedral particles. X-ray crystallographic analysis of these particles at 3.5 A resolution shows that L1 closely resembles VP1 from polyomaviruses. Surface loops contain the sites of sequence variation among HPV types and the locations of dominant neutralizing epitopes. The ease with which small virus-like particles may be obtained from L1 expressed in E. coli makes them attractive candidate components of a papillomavirus vaccine. Their crystal structure also provides a starting point for future vaccine design. Structure of small virus-like particles assembled from the L1 protein of human papillomavirus 16.,Chen XS, Garcea RL, Goldberg I, Casini G, Harrison SC Mol Cell. 2000 Mar;5(3):557-67. PMID:10882140[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences |
| ||||||||||||||