1eik: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1eik]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EIK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EIK FirstGlance]. <br> | <table><tr><td colspan='2'>[[1eik]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EIK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EIK FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] </span></td></tr> | </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] </span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1eik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eik OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1eik RCSB], [http://www.ebi.ac.uk/pdbsum/1eik PDBsum], [http://www.topsan.org/Proteins/NESGC/1eik TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1eik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eik OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1eik RCSB], [http://www.ebi.ac.uk/pdbsum/1eik PDBsum], [http://www.topsan.org/Proteins/NESGC/1eik TOPSAN]</span></td></tr> | ||
<table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: DNA-directed RNA polymerase]] | [[Category: DNA-directed RNA polymerase]] | ||
[[Category: Methanothermobacter thermautotrophicus]] | [[Category: Methanothermobacter thermautotrophicus]] | ||
[[Category: Arrowsmith, C H | [[Category: Arrowsmith, C H]] | ||
[[Category: Booth, V | [[Category: Booth, V]] | ||
[[Category: Dharamsi, A | [[Category: Dharamsi, A]] | ||
[[Category: Edwards, A M | [[Category: Edwards, A M]] | ||
[[Category: Engel, A | [[Category: Engel, A]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Yee, A | [[Category: Yee, A]] | ||
[[Category: Nesg]] | [[Category: Nesg]] | ||
[[Category: Ocsp]] | [[Category: Ocsp]] | ||
[[Category: Protein structure initiative | [[Category: PSI, Protein structure initiative]] | ||
[[Category: Rna polymerase subunit]] | [[Category: Rna polymerase subunit]] | ||
[[Category: Rpb5]] | [[Category: Rpb5]] | ||
[[Category: Rpbh]] | [[Category: Rpbh]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 21:55, 22 December 2014
Solution Structure of RNA Polymerase Subunit RPB5 from Methanobacterium ThermoautotrophicumSolution Structure of RNA Polymerase Subunit RPB5 from Methanobacterium Thermoautotrophicum
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedRPB5 is an essential subunit of eukaryotic and archaeal RNA polymerases. It is a proposed target for transcription activator proteins in eukaryotes, but the mechanism of interaction is not known. We have determined the solution structure of the RPB5 subunit from the thermophilic archeon, Methanobacterium thermoautotrophicum. MtRBP5 contains a four-stranded beta-sheet platform supporting two alpha-helices, one on each side of the beta-sheet, resulting in an overall mushroom shape that does not appear to have any structural homologues in the structural database. The position and conservation of charged surface residues suggests possible modes of interaction with other proteins, as well as a rationale for the thermal stability of this protein. Solution structure of the RNA polymerase subunit RPB5 from Methanobacterium thermoautotrophicum.,Yee A, Booth V, Dharamsi A, Engel A, Edwards AM, Arrowsmith CH Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6311-5. PMID:10841538[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences |
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