1uai: Difference between revisions
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'''Crystal Structure of the Alginate Lyase from Corynebacterium sp.''' | {{Structure | ||
|PDB= 1uai |SIZE=350|CAPTION= <scene name='initialview01'>1uai</scene>, resolution 1.20Å | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= [http://en.wikipedia.org/wiki/Poly(alpha-L-guluronate)_lyase Poly(alpha-L-guluronate) lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.2.11 4.2.2.11] | |||
|GENE= | |||
}} | |||
'''Crystal Structure of the Alginate Lyase from Corynebacterium sp.''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1UAI is a [ | 1UAI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Corynebacterium_sp. Corynebacterium sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UAI OCA]. | ||
==Reference== | ==Reference== | ||
Crystal structure of the alginate (poly alpha-l-guluronate) lyase from Corynebacterium sp. at 1.2 A resolution., Osawa T, Matsubara Y, Muramatsu T, Kimura M, Kakuta Y, J Mol Biol. 2005 Feb 4;345(5):1111-8. Epub 2004 Dec 13. PMID:[http:// | Crystal structure of the alginate (poly alpha-l-guluronate) lyase from Corynebacterium sp. at 1.2 A resolution., Osawa T, Matsubara Y, Muramatsu T, Kimura M, Kakuta Y, J Mol Biol. 2005 Feb 4;345(5):1111-8. Epub 2004 Dec 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15644208 15644208] | ||
[[Category: Corynebacterium sp.]] | [[Category: Corynebacterium sp.]] | ||
[[Category: Poly(alpha-L-guluronate) lyase]] | [[Category: Poly(alpha-L-guluronate) lyase]] | ||
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[[Category: jellyroll beta-sandwich]] | [[Category: jellyroll beta-sandwich]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:29:26 2008'' | ||
Revision as of 15:29, 20 March 2008
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| , resolution 1.20Å | |||||||
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| Activity: | Poly(alpha-L-guluronate) lyase, with EC number 4.2.2.11 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of the Alginate Lyase from Corynebacterium sp.
OverviewOverview
The crystal structure of alginate (poly alpha-l-guluronate) lyase from Corynebacterium sp. (ALY-1) was determined at 1.2A resolution using the MAD method and bromide ions. The structure of ALY-1 is abundant in beta-strands and has a deep cleft, similar to the jellyroll beta-sandwich found in 1,3-1,4-beta-glucanase. The structure suggests that alginate molecules may penetrate into the cleft to interact with the catalytic site of ALY-1. The reported crystal structure of another type of alginate lyase, A1-III, differs from that of ALY-1 in that it consists almost entirely of alpha-helical structure. Nevertheless, the putative catalytic residues in both enzymes are positioned in space in nearly identical arrangements. This finding suggests that both alginate lyases may have evolved through convergent evolution.
About this StructureAbout this Structure
1UAI is a Single protein structure of sequence from Corynebacterium sp.. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of the alginate (poly alpha-l-guluronate) lyase from Corynebacterium sp. at 1.2 A resolution., Osawa T, Matsubara Y, Muramatsu T, Kimura M, Kakuta Y, J Mol Biol. 2005 Feb 4;345(5):1111-8. Epub 2004 Dec 13. PMID:15644208
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