1uoj: Difference between revisions

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-{{STRUCTURE_1uoj|  PDB=1uoj  |  SCENE=  }}
+==CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA LECTIN 1 IN THE CALCIUM-FREE STATE==
-===CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA LECTIN 1 IN THE CALCIUM-FREE STATE===
+<StructureSection load='1uoj' size='340' side='right' caption='[[1uoj]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-{{ABSTRACT_PUBMED_14644431}}
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1uoj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UOJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UOJ FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1l7l|1l7l]], [[1oko|1oko]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uoj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uoj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uoj RCSB], [http://www.ebi.ac.uk/pdbsum/1uoj PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The structure of the tetrameric Pseudomonas aeruginosa lectin I (PA-IL) in complex with galactose and calcium was determined at 1.6 A resolution, and the native protein was solved at 2.4 A resolution. Each monomer adopts a beta-sandwich fold with ligand binding site at the apex. All galactose hydroxyl groups, except O1, are involved in a hydrogen bond network with the protein and O3 and O4 also participate in the co-ordination of the calcium ion. The stereochemistry of calcium galactose binding is reminiscent of that observed in some animal C-type lectins. The structure of the complex provides a framework for future design of anti-bacterial compounds.
-==Function==
+Structural basis of calcium and galactose recognition by the lectin PA-IL of Pseudomonas aeruginosa.,Cioci G, Mitchell EP, Gautier C, Wimmerova M, Sudakevitz D, Perez S, Gilboa-Garber N, Imberty A FEBS Lett. 2003 Dec 4;555(2):297-301. PMID:14644431<ref>PMID:14644431</ref>
-[[http://www.uniprot.org/uniprot/PA1L_PSEAE PA1L_PSEAE]] D-galactose specific lectin. Binds in decreasing order of affinity: melibiose, methyl-alpha-D-galactoside, D-galactose, methyl-beta-D-galactoside, N-acetyl-D-galactosamine. Similar to plant lectins in its selective (carbohydrate-specific) hemagglutinating activity.
-==About this Structure==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[1uoj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UOJ OCA].
+</div>
 ==See Also==
 *[[Galactose-binding lectin|Galactose-binding lectin]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:014644431</ref><references group="xtra"/><references/>
+__TOC__
+</StructureSection>
 [[Category: Pseudomonas aeruginosa]]
-[[Category: Cioci, G.]]
+[[Category: Cioci, G]]
-[[Category: Gautier, C.]]
+[[Category: Gautier, C]]
-[[Category: Gilboa-Garber, N.]]
+[[Category: Gilboa-Garber, N]]
-[[Category: Imberty, A.]]
+[[Category: Imberty, A]]
-[[Category: Mitchell, E.]]
+[[Category: Mitchell, E]]
-[[Category: Perez, S.]]
+[[Category: Perez, S]]
-[[Category: Wimmerova, M.]]
+[[Category: Wimmerova, M]]
 [[Category: Galactose binding]]
 [[Category: Sugar binding protein]]