1tdg: Difference between revisions
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[[Image:1tdg.jpg|left|200px]] | [[Image:1tdg.jpg|left|200px]] | ||
'''Complex of S130G SHV-1 beta-lactamase with tazobactam''' | {{Structure | ||
|PDB= 1tdg |SIZE=350|CAPTION= <scene name='initialview01'>1tdg</scene>, resolution 1.8Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=MA4:CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE'>MA4</scene>, <scene name='pdbligand=TBE:TAZOBACTAM+INTERMEDIATE'>TBE</scene>, <scene name='pdbligand=MDD:MALONALDEHYDE'>MDD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene> and <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene> | |||
|ACTIVITY= [http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] | |||
|GENE= bla ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 Klebsiella pneumoniae]) | |||
}} | |||
'''Complex of S130G SHV-1 beta-lactamase with tazobactam''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1TDG is a [ | 1TDG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TDG OCA]. | ||
==Reference== | ==Reference== | ||
Inhibitor-resistant class A beta-lactamases: consequences of the Ser130-to-Gly mutation seen in Apo and tazobactam structures of the SHV-1 variant., Sun T, Bethel CR, Bonomo RA, Knox JR, Biochemistry. 2004 Nov 9;43(44):14111-7. PMID:[http:// | Inhibitor-resistant class A beta-lactamases: consequences of the Ser130-to-Gly mutation seen in Apo and tazobactam structures of the SHV-1 variant., Sun T, Bethel CR, Bonomo RA, Knox JR, Biochemistry. 2004 Nov 9;43(44):14111-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15518561 15518561] | ||
[[Category: Beta-lactamase]] | [[Category: Beta-lactamase]] | ||
[[Category: Klebsiella pneumoniae]] | [[Category: Klebsiella pneumoniae]] | ||
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[[Category: tazobactam]] | [[Category: tazobactam]] | ||
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