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{{STRUCTURE_4lg8|  PDB=4lg8  |  SCENE=  }}
==Crystal structure of PRPF19 WD40 repeats==
===Crystal structure of PRPF19 WD40 repeats===
<StructureSection load='4lg8' size='340' side='right' caption='[[4lg8]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[4lg8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LG8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LG8 FirstGlance]. <br>
[[http://www.uniprot.org/uniprot/PRP19_HUMAN PRP19_HUMAN]] Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.<ref>PMID:11082287</ref> <ref>PMID:12960389</ref> <ref>PMID:16332694</ref> <ref>PMID:15660529</ref> <ref>PMID:16223718</ref> <ref>PMID:16388800</ref>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
 
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PRPF19, NMP200, PRP19, SNEV ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lg8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lg8 RCSB], [http://www.ebi.ac.uk/pdbsum/4lg8 PDBsum]</span></td></tr>
[[4lg8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LG8 OCA].  
</table>
 
__TOC__
==Reference==
</StructureSection>
<references group="xtra"/><references/>
[[Category: Human]]
[[Category: Human]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith, C H]]
[[Category: Bountra, C.]]
[[Category: Bountra, C]]
[[Category: Dobrovetsky, E.]]
[[Category: Dobrovetsky, E]]
[[Category: Edwards, A M.]]
[[Category: Edwards, A M]]
[[Category: He, H.]]
[[Category: He, H]]
[[Category: Min, J.]]
[[Category: Min, J]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Structural genomic]]
[[Category: Tempel, W.]]
[[Category: Tempel, W]]
[[Category: Xu, C.]]
[[Category: Xu, C]]
[[Category: Dna binding protein]]
[[Category: Dna binding protein]]
[[Category: Sgc]]
[[Category: Sgc]]
[[Category: Structural genomics consortium]]
[[Category: Wd40 repeat]]
[[Category: Wd40 repeat]]

Revision as of 21:58, 21 December 2014

Crystal structure of PRPF19 WD40 repeatsCrystal structure of PRPF19 WD40 repeats

Structural highlights

4lg8 is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Gene:PRPF19, NMP200, PRP19, SNEV (HUMAN)
Resources:FirstGlance, OCA, RCSB, PDBsum

4lg8, resolution 1.89Å

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