4mlk: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==3.05A resolution structure of CT584 from Chlamydia trachomatis== | |||
<StructureSection load='4mlk' size='340' side='right' caption='[[4mlk]], [[Resolution|resolution]] 3.05Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4mlk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chlt2 Chlt2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MLK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MLK FirstGlance]. <br> | |||
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTL0847 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=471472 CHLT2])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mlk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mlk RCSB], [http://www.ebi.ac.uk/pdbsum/4mlk PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Chlamydia trachomatis is a major cause of various diseases, including blinding trachoma and pelvic inflammatory disease, and is the leading reported sexually transmitted bacterial infection worldwide. All pathogenic Chlamydiae spp. utilize a supramolecular syringe, or type III secretion system (T3SS), to inject proteins into their obligate host in order to propagate infection. Here, the structure of CT584, a T3SS-associated protein, that has been refined to a resolution of 3.05 A is reported. The CT584 structure is a hexamer comprised of a trimer of dimers. The structure shares a high degree of similarity to the recently reported structure of an orthologous protein, Cpn0803, from Chlamydia pneumoniae, which highlights the highly conserved nature of this protein across these chlamydial species, despite different tissue tropism and disease pathology. | |||
Structure of CT584 from Chlamydia trachomatis refined to 3.05 A resolution.,Barta ML, Hickey J, Kemege KE, Lovell S, Battaile KP, Hefty PS Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Nov;69(Pt 11):1196-201., doi: 10.1107/S1744309113027371. Epub 2013 Oct 26. PMID:24192348<ref>PMID:24192348</ref> | |||
== | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Chlt2]] | [[Category: Chlt2]] | ||
[[Category: Barta, M L | [[Category: Barta, M L]] | ||
[[Category: Battaile, K P | [[Category: Battaile, K P]] | ||
[[Category: Hefty, P S | [[Category: Hefty, P S]] | ||
[[Category: Hickey, J | [[Category: Hickey, J]] | ||
[[Category: Kemege, K | [[Category: Kemege, K]] | ||
[[Category: Lovell, S | [[Category: Lovell, S]] | ||
[[Category: Chlamydia]] | [[Category: Chlamydia]] | ||
[[Category: Ct584]] | [[Category: Ct584]] | ||
[[Category: Hypothetical protein]] | [[Category: Hypothetical protein]] | ||
[[Category: Unknown function]] | [[Category: Unknown function]] | ||
Revision as of 20:40, 21 December 2014
3.05A resolution structure of CT584 from Chlamydia trachomatis3.05A resolution structure of CT584 from Chlamydia trachomatis
Structural highlights
Publication Abstract from PubMedChlamydia trachomatis is a major cause of various diseases, including blinding trachoma and pelvic inflammatory disease, and is the leading reported sexually transmitted bacterial infection worldwide. All pathogenic Chlamydiae spp. utilize a supramolecular syringe, or type III secretion system (T3SS), to inject proteins into their obligate host in order to propagate infection. Here, the structure of CT584, a T3SS-associated protein, that has been refined to a resolution of 3.05 A is reported. The CT584 structure is a hexamer comprised of a trimer of dimers. The structure shares a high degree of similarity to the recently reported structure of an orthologous protein, Cpn0803, from Chlamydia pneumoniae, which highlights the highly conserved nature of this protein across these chlamydial species, despite different tissue tropism and disease pathology. Structure of CT584 from Chlamydia trachomatis refined to 3.05 A resolution.,Barta ML, Hickey J, Kemege KE, Lovell S, Battaile KP, Hefty PS Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Nov;69(Pt 11):1196-201., doi: 10.1107/S1744309113027371. Epub 2013 Oct 26. PMID:24192348[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
|
| ||||||||||||||||