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{{STRUCTURE_2m45|  PDB=2m45  |  SCENE=  }}
==NMR solution structure of the C-terminus of the minichromosome maintenance protein MCM from Sulfolobus solfataricus==
===NMR solution structure of the C-terminus of the minichromosome maintenance protein MCM from Sulfolobus solfataricus===
<StructureSection load='2m45' size='340' side='right' caption='[[2m45]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[2m45]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulso Sulso]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M45 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M45 FirstGlance]. <br>
[[http://www.uniprot.org/uniprot/MCM_SULSO MCM_SULSO]] Presumptive replicative helicase. Has ATPase and DNA helicase activities. The latter preferentially melts 5'-tailed oligonucleotides and is stimulated by the SSB protein (single-stranded DNA binding protein). The active ATPase sites in the MCM ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The helicase function is proposed to use a partially sequential mode of ATP hydrolysis; the complex appears to tolerate multiple catalytically inactive subunits.<ref>PMID:11821426</ref>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MCM, SSO0774 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=273057 SULSO])</td></tr>
 
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_helicase DNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.12 3.6.4.12] </span></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m45 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m45 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m45 RCSB], [http://www.ebi.ac.uk/pdbsum/2m45 PDBsum]</span></td></tr>
[[2m45]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M45 OCA].  
</table>
 
__TOC__
==Reference==
</StructureSection>
<references group="xtra"/><references/>
[[Category: DNA helicase]]
[[Category: DNA helicase]]
[[Category: Gorlach, M.]]
[[Category: Sulso]]
[[Category: Medagli, B.]]
[[Category: Gorlach, M]]
[[Category: Ohlenschlager, O.]]
[[Category: Medagli, B]]
[[Category: Onesti, S.]]
[[Category: Ohlenschlager, O]]
[[Category: Wiedemann, C.]]
[[Category: Onesti, S]]
[[Category: Wiedemann, C]]
[[Category: Dna helicase]]
[[Category: Dna helicase]]
[[Category: Helix-turn-helix]]
[[Category: Helix-turn-helix]]

Revision as of 20:22, 21 December 2014

NMR solution structure of the C-terminus of the minichromosome maintenance protein MCM from Sulfolobus solfataricusNMR solution structure of the C-terminus of the minichromosome maintenance protein MCM from Sulfolobus solfataricus

Structural highlights

2m45 is a 1 chain structure with sequence from Sulso. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:MCM, SSO0774 (SULSO)
Activity:DNA helicase, with EC number 3.6.4.12
Resources:FirstGlance, OCA, RCSB, PDBsum
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