4mz1: Difference between revisions

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{{STRUCTURE_4mz1|  PDB=4mz1  |  SCENE=  }}
==Crystal Structure of the Inosine 5'-monophosphate Dehydrogenase, with a Internal Deletion of CBS Domain from Campylobacter jejuni complexed with inhibitor compound P12==
===Crystal Structure of the Inosine 5'-monophosphate Dehydrogenase, with a Internal Deletion of CBS Domain from Campylobacter jejuni complexed with inhibitor compound P12===
<StructureSection load='4mz1' size='340' side='right' caption='[[4mz1]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4mz1]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Camje Camje]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MZ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MZ1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2F1:1-(4-BROMOPHENYL)-3-{2-[3-(PROP-1-EN-2-YL)PHENYL]PROPAN-2-YL}UREA'>2F1</scene>, <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">guaB, Cj1058c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=192222 CAMJE])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mz1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mz1 RCSB], [http://www.ebi.ac.uk/pdbsum/4mz1 PDBsum]</span></td></tr>
</table>


==Function==
==See Also==
[[http://www.uniprot.org/uniprot/Q0P9J4_CAMJE Q0P9J4_CAMJE]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity).[HAMAP-Rule:MF_01964]  
*[[Inosine monophosphate dehydrogenase|Inosine monophosphate dehydrogenase]]
 
__TOC__
==About this Structure==
</StructureSection>
[[4mz1]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MZ1 OCA].
[[Category: Camje]]
[[Category: IMP dehydrogenase]]
[[Category: IMP dehydrogenase]]
[[Category: Anderson, W F.]]
[[Category: Anderson, W F]]
[[Category: CSGID, Center for Structural Genomics of Infectious Diseases.]]
[[Category: Structural genomic]]
[[Category: Csgid]]
[[Category: Csgid]]
[[Category: Gu, M.]]
[[Category: Gu, M]]
[[Category: Joachimiak, A.]]
[[Category: Joachimiak, A]]
[[Category: Kim, Y.]]
[[Category: Kim, Y]]
[[Category: Makowska-Grzyska, M.]]
[[Category: Makowska-Grzyska, M]]
[[Category: Alpha-beta structure]]
[[Category: Alpha-beta structure]]
[[Category: Center for structural genomics of infectious disease]]
[[Category: Csgid]]
[[Category: National institute of allergy and infectious disease]]
[[Category: National institute of allergy and infectious disease]]
[[Category: Niaid]]
[[Category: Niaid]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
[[Category: Structural genomic]]
[[Category: Tim barrel]]
[[Category: Tim barrel]]

Revision as of 20:11, 21 December 2014

Crystal Structure of the Inosine 5'-monophosphate Dehydrogenase, with a Internal Deletion of CBS Domain from Campylobacter jejuni complexed with inhibitor compound P12Crystal Structure of the Inosine 5'-monophosphate Dehydrogenase, with a Internal Deletion of CBS Domain from Campylobacter jejuni complexed with inhibitor compound P12

Structural highlights

4mz1 is a 3 chain structure with sequence from Camje. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , , , ,
Gene:guaB, Cj1058c (CAMJE)
Activity:IMP dehydrogenase, with EC number 1.1.1.205
Resources:FirstGlance, OCA, RCSB, PDBsum

See Also

4mz1, resolution 2.40Å

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