4j5c: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older editNewer edit →
No edit summary
No edit summary
Line 1: Line 1:
{{STRUCTURE_4j5c| PDB=4j5c | SCENE= }}  
==Human Cyclophilin D Complexed with an Inhibitor==
===Human Cyclophilin D Complexed with an Inhibitor===
<StructureSection load='4j5c' size='340' side='right' caption='[[4j5c]], [[Resolution|resolution]] 1.03&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4j5c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J5C FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7I6:1-(4-AMINOBENZYL)-3-[(2S)-4-(METHYLSULFANYL)-1-{(2R)-2-[2-(METHYLSULFANYL)PHENYL]PYRROLIDIN-1-YL}-1-OXOBUTAN-2-YL]UREA'>7I6</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4j58|4j58]], [[4j59|4j59]], [[4j5a|4j5a]], [[4j5b|4j5b]], [[4j5d|4j5d]], [[4j5e|4j5e]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYP3, PPIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j5c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j5c RCSB], [http://www.ebi.ac.uk/pdbsum/4j5c PDBsum]</span></td></tr>
</table>


==Function==
==See Also==
[[http://www.uniprot.org/uniprot/PPIF_HUMAN PPIF_HUMAN]] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probablity of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.<ref>PMID:19228691</ref> <ref>PMID:22726440</ref> 
*[[Cyclophilin|Cyclophilin]]
 
__TOC__
==About this Structure==
</StructureSection>
[[4j5c]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J5C OCA].
[[Category: Human]]
 
==Reference==
<references group="xtra"/><references/>
[[Category: Peptidylprolyl isomerase]]
[[Category: Peptidylprolyl isomerase]]
[[Category: Bessin, Y.]]
[[Category: Bessin, Y]]
[[Category: Colliandre, L.]]
[[Category: Colliandre, L]]
[[Category: Gelin, M.]]
[[Category: Gelin, M]]
[[Category: Guichou, J F.]]
[[Category: Guichou, J F]]
[[Category: Isomerase-isomerase inhibitor complex]]
[[Category: Isomerase-isomerase inhibitor complex]]

Revision as of 19:54, 21 December 2014

Human Cyclophilin D Complexed with an InhibitorHuman Cyclophilin D Complexed with an Inhibitor

Structural highlights

4j5c is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Gene:CYP3, PPIF (HUMAN)
Activity:Peptidylprolyl isomerase, with EC number 5.2.1.8
Resources:FirstGlance, OCA, RCSB, PDBsum

See Also

4j5c, resolution 1.03Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=4j5c&oldid=2148184"