1sp7: Difference between revisions

Revision as of 15:07, 20 March 2008

Coordinates:

Structure of the Cys-rich C-terminal domain of Hydra minicollagen

OverviewOverview

A high-precision solution structure of the C-terminal minicollagen cysteine rich domain of Hydra has been determined using modern heteronuclear and weak alignment NMR techniques at natural isotope abundance. The domain consists of only 24 amino acids, six of which are prolines and six are cysteines bonded in disulfide bridges that constrain the structure into a new fold. The redox equilibrium of the structure has been characterized from a titration with glutathione. No local native structures are detectable in the reduced form. Thus, oxidation and folding are tightly coupled.

About this StructureAbout this Structure

1SP7 is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.

ReferenceReference

Determination of a high-precision NMR structure of the minicollagen cysteine rich domain from Hydra and characterization of its disulfide bond formation., Meier S, Haussinger D, Pokidysheva E, Bachinger HP, Grzesiek S, FEBS Lett. 2004 Jul 2;569(1-3):112-6. PMID:15225618

Page seeded by OCA on Thu Mar 20 14:07:53 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:1sp7.gif|left|200px]]<br /><applet load="1sp7" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1sp7.gif|left|200px]]
-caption="1sp7" />
-'''Structure of the Cys-rich C-terminal domain of Hydra minicollagen'''<br />
+ {{Structure
+|PDB= 1sp7 |SIZE=350|CAPTION= <scene name='initialview01'>1sp7</scene>
+|SITE=
+|LIGAND=
+|ACTIVITY=
+|GENE=
+}}
+'''Structure of the Cys-rich C-terminal domain of Hydra minicollagen'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-SP7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SP7 OCA].
+SP7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SP7 OCA].
 ==Reference==
-Determination of a high-precision NMR structure of the minicollagen cysteine rich domain from Hydra and characterization of its disulfide bond formation., Meier S, Haussinger D, Pokidysheva E, Bachinger HP, Grzesiek S, FEBS Lett. 2004 Jul 2;569(1-3):112-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15225618 15225618]
+Determination of a high-precision NMR structure of the minicollagen cysteine rich domain from Hydra and characterization of its disulfide bond formation., Meier S, Haussinger D, Pokidysheva E, Bachinger HP, Grzesiek S, FEBS Lett. 2004 Jul 2;569(1-3):112-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15225618 15225618]
 [[Category: Single protein]]
 [[Category: Bachinger, H P.]]
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 [[Category: proline-rich]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:03:47 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:07:53 2008''