1sm2: Difference between revisions
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[[Image:1sm2.jpg|left|200px]] | [[Image:1sm2.jpg|left|200px]] | ||
'''Crystal structure of the phosphorylated Interleukin-2 tyrosine kinase catalytic domain''' | {{Structure | ||
|PDB= 1sm2 |SIZE=350|CAPTION= <scene name='initialview01'>1sm2</scene>, resolution 2.3Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=STU:STAUROSPORINE'>STU</scene> | |||
|ACTIVITY= [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] | |||
|GENE= ITK, LYK, EMT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |||
}} | |||
'''Crystal structure of the phosphorylated Interleukin-2 tyrosine kinase catalytic domain''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1SM2 is a [ | 1SM2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SM2 OCA]. | ||
==Reference== | ==Reference== | ||
Crystal structures of interleukin-2 tyrosine kinase and their implications for the design of selective inhibitors., Brown K, Long JM, Vial SC, Dedi N, Dunster NJ, Renwick SB, Tanner AJ, Frantz JD, Fleming MA, Cheetham GM, J Biol Chem. 2004 Apr 30;279(18):18727-32. Epub 2004 Feb 6. PMID:[http:// | Crystal structures of interleukin-2 tyrosine kinase and their implications for the design of selective inhibitors., Brown K, Long JM, Vial SC, Dedi N, Dunster NJ, Renwick SB, Tanner AJ, Frantz JD, Fleming MA, Cheetham GM, J Biol Chem. 2004 Apr 30;279(18):18727-32. Epub 2004 Feb 6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14766749 14766749] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: protein kinase]] | [[Category: protein kinase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:06:46 2008'' | ||
Revision as of 15:06, 20 March 2008
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| , resolution 2.3Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | ITK, LYK, EMT (Homo sapiens) | ||||||
| Activity: | Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of the phosphorylated Interleukin-2 tyrosine kinase catalytic domain
OverviewOverview
Interleukin-2 tyrosine kinase, Itk, is an important member of the Tec family of non-receptor tyrosine kinases that play a central role in signaling through antigen receptors such as the T-cell receptor, B-cell receptor, and Fcepsilon. Selective inhibition of Itk may be an important way of modulating many diseases involving heightened or inappropriate activation of the immune system. In addition to an unliganded nonphophorylated Itk catalytic kinase domain, we determined the crystal structures of the phosphorylated and nonphosphorylated kinase domain bound to staurosporine, a potent broad-spectrum kinase inhibitor. These structures are useful for the design of novel, highly potent and selective Itk inhibitors and provide insight into the influence of inhibitor binding and phosphorylation on the conformation of Itk.
DiseaseDisease
Known disease associated with this structure: Polyhydramnios, megalencephaly, and symptomatic epilepsy OMIM:[608626]
About this StructureAbout this Structure
1SM2 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structures of interleukin-2 tyrosine kinase and their implications for the design of selective inhibitors., Brown K, Long JM, Vial SC, Dedi N, Dunster NJ, Renwick SB, Tanner AJ, Frantz JD, Fleming MA, Cheetham GM, J Biol Chem. 2004 Apr 30;279(18):18727-32. Epub 2004 Feb 6. PMID:14766749
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