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{{STRUCTURE_4mso|  PDB=4mso  |  SCENE=  }}
==X-ray crystal structure of a serine hydroxymethyl transferase in apo form from Burkholderia cenocepacia==
===X-ray crystal structure of a serine hydroxymethyl transferase in apo form from Burkholderia cenocepacia===
<StructureSection load='4mso' size='340' side='right' caption='[[4mso]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4mso]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Burcj Burcj]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MSO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MSO FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">glyA, glyA1, BceJ2315_31420, BCAL3197 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216591 BURCJ])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine_hydroxymethyltransferase Glycine hydroxymethyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.1 2.1.2.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mso OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mso RCSB], [http://www.ebi.ac.uk/pdbsum/4mso PDBsum]</span></td></tr>
</table>


==Function==
==See Also==
[[http://www.uniprot.org/uniprot/B4ECY9_BURCJ B4ECY9_BURCJ]] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity).[HAMAP-Rule:MF_00051]  
*[[Serine hydroxymethyltransferase|Serine hydroxymethyltransferase]]
 
__TOC__
==About this Structure==
</StructureSection>
[[4mso]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MSO OCA].
[[Category: Burcj]]
[[Category: Glycine hydroxymethyltransferase]]
[[Category: Glycine hydroxymethyltransferase]]
[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]
[[Category: Structural genomic]]
[[Category: National institute of allergy and infectious disease]]
[[Category: National institute of allergy and infectious disease]]
[[Category: Niaid]]
[[Category: Niaid]]
[[Category: Pyridoxal phosphate]]
[[Category: Pyridoxal phosphate]]
[[Category: Seattle structural genomics center for infectious disease]]
[[Category: Serine hydroxymethyl transferase]]
[[Category: Serine hydroxymethyl transferase]]
[[Category: Ssgcid]]
[[Category: Ssgcid]]
[[Category: Structural genomic]]
[[Category: Transferase]]
[[Category: Transferase]]

Revision as of 19:23, 21 December 2014

X-ray crystal structure of a serine hydroxymethyl transferase in apo form from Burkholderia cenocepaciaX-ray crystal structure of a serine hydroxymethyl transferase in apo form from Burkholderia cenocepacia

Structural highlights

4mso is a 2 chain structure with sequence from Burcj. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Gene:glyA, glyA1, BceJ2315_31420, BCAL3197 (BURCJ)
Activity:Glycine hydroxymethyltransferase, with EC number 2.1.2.1
Resources:FirstGlance, OCA, RCSB, PDBsum

See Also

4mso, resolution 1.40Å

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