1s03: Difference between revisions
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[[Image:1s03.gif|left|200px]] | [[Image:1s03.gif|left|200px]] | ||
'''The Structure of a Ribosomal Protein S8/spc Operon mRNA Complex''' | {{Structure | ||
|PDB= 1s03 |SIZE=350|CAPTION= <scene name='initialview01'>1s03</scene>, resolution 2.70Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''The Structure of a Ribosomal Protein S8/spc Operon mRNA Complex''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1S03 is a [ | 1S03 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S03 OCA]. | ||
==Reference== | ==Reference== | ||
The structure of a ribosomal protein S8/spc operon mRNA complex., Merianos HJ, Wang J, Moore PB, RNA. 2004 Jun;10(6):954-64. PMID:[http:// | The structure of a ribosomal protein S8/spc operon mRNA complex., Merianos HJ, Wang J, Moore PB, RNA. 2004 Jun;10(6):954-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15146079 15146079] | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: spc operon]] | [[Category: spc operon]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:58:39 2008'' | ||
Revision as of 14:58, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
The Structure of a Ribosomal Protein S8/spc Operon mRNA Complex
OverviewOverview
In bacteria, translation of all the ribosomal protein cistrons in the spc operon mRNA is repressed by the binding of the product of one of them, S8, to an internal sequence at the 5' end of the L5 cistron. The way in which the first two genes of the spc operon are regulated, retroregulation, is mechanistically distinct from translational repression by S8 of the genes from L5 onward. A 2.8 A resolution crystal structure has been obtained of Escherichia coli S8 bound to this site. Despite sequence differences, the structure of this complex is almost identical to that of the S8/helix 21 complex seen in the small ribosomal subunit, consistent with the hypothesis that autogenous regulation of ribosomal protein synthesis results from conformational similarities between mRNAs and rRNAs. S8 binding must repress the translation of its own mRNA by inhibiting the formation of a ribosomal initiation complex at the start of the L5 cistron.
About this StructureAbout this Structure
1S03 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
ReferenceReference
The structure of a ribosomal protein S8/spc operon mRNA complex., Merianos HJ, Wang J, Moore PB, RNA. 2004 Jun;10(6):954-64. PMID:15146079
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