1rz4: Difference between revisions

← Older edit Newer edit →

Revision as of 14:58, 20 March 2008

File:1rz4.jpg

, resolution 2.1Å

Ligands:

Coordinates:

save as pdb, mmCIF, xml

Crystal Structure of Human eIF3k

OverviewOverview

eIF3k, the smallest subunit of eukaryotic initiation factor 3 (eIF3), interacts with several other subunits of eIF3 and the 40 S ribosomal subunit. eIF3k is conserved among high eukaryotes, including mammals, insects, and plants, and it is ubiquitously expressed in human tissues. Interestingly, eIF3k does not exist in some species of yeast. Thus, eIF3k may play a unique regulatory role in higher organisms. Here we report the crystal structure of human eIF3k, the first high-resolution structure of an eIF3 component. This novel structure contains two distinct domains, a HEAT (named for Huntington, elongation factor 3, A subunit of protein phosphatase 2A, target of rapamycin) repeat-like HAM (HEAT analogous motif) domain and a winged-helix-like WH domain. Through structural comparison and sequence conservation analysis, we show that eIF3k has three putative protein-binding surfaces and has potential RNA binding activity. The structure provides key information for understanding the structure and function of the eIF3 complex.

About this StructureAbout this Structure

1RZ4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of human eIF3k, the first structure of eIF3 subunits., Wei Z, Zhang P, Zhou Z, Cheng Z, Wan M, Gong W, J Biol Chem. 2004 Aug 13;279(33):34983-90. Epub 2004 Jun 4. PMID:15180986

Page seeded by OCA on Thu Mar 20 13:58:16 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1rz4.jpg|left|200px]]<br /><applet load="1rz4" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1rz4.jpg|left|200px]]
-caption="1rz4, resolution 2.1&Aring;" />
-'''Crystal Structure of Human eIF3k'''<br />
+ {{Structure
+|PDB= 1rz4 |SIZE=350|CAPTION= <scene name='initialview01'>1rz4</scene>, resolution 2.1&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
+|ACTIVITY=
+|GENE=
+}}
+'''Crystal Structure of Human eIF3k'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-RZ4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZ4 OCA].
+RZ4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZ4 OCA].
 ==Reference==
-Crystal structure of human eIF3k, the first structure of eIF3 subunits., Wei Z, Zhang P, Zhou Z, Cheng Z, Wan M, Gong W, J Biol Chem. 2004 Aug 13;279(33):34983-90. Epub 2004 Jun 4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15180986 15180986]
+Crystal structure of human eIF3k, the first structure of eIF3 subunits., Wei Z, Zhang P, Zhou Z, Cheng Z, Wan M, Gong W, J Biol Chem. 2004 Aug 13;279(33):34983-90. Epub 2004 Jun 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15180986 15180986]
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
@@ Line 21: / Line 30: @@
 [[Category: winged-helix]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:56:07 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:58:16 2008''