1rxl: Difference between revisions

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Revision as of 14:57, 20 March 2008

File:1rxl.gif

Gene:

afae3 (Escherichia coli)

Coordinates:

save as pdb, mmCIF, xml

Solution structure of the engineered protein Afae-dsc

OverviewOverview

Pathogenic bacteria possess adhesion protein complexes that play essential roles in targeting host cells and in propagating infection. Although each family of adhesion proteins is generally associated with a specific human disease, the Dr family from Escherichia coli is a notable exception, as its members are associated with both diarrheal and urinary tract infections. These proteins are reported to form both fimbrial and afimbrial structures at the bacterial cell surface and target a common host cell receptor, the decay-accelerating factor (DAF or CD55). Using the newly solved three-dimensional structure of AfaE, we have constructed a robust atomic resolution model that reveals the structural basis for assembly by donor strand complementation and for the architecture of capped surface fibers.

About this StructureAbout this Structure

1RXL is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

ReferenceReference

An atomic resolution model for assembly, architecture, and function of the Dr adhesins., Anderson KL, Billington J, Pettigrew D, Cota E, Simpson P, Roversi P, Chen HA, Urvil P, du Merle L, Barlow PN, Medof ME, Smith RA, Nowicki B, Le Bouguenec C, Lea SM, Matthews S, Mol Cell. 2004 Aug 27;15(4):647-57. PMID:15327779

Page seeded by OCA on Thu Mar 20 13:57:34 2008

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OCA

@@ Line 1: / Line 1: @@
-[[Image:1rxl.gif|left|200px]]<br /><applet load="1rxl" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1rxl.gif|left|200px]]
-caption="1rxl" />
-'''Solution structure of the engineered protein Afae-dsc'''<br />
+ {{Structure
+|PDB= 1rxl |SIZE=350|CAPTION= <scene name='initialview01'>1rxl</scene>
+|SITE=
+|LIGAND=
+|ACTIVITY=
+|GENE= afae3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
+}}
+'''Solution structure of the engineered protein Afae-dsc'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-RXL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RXL OCA].
+RXL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RXL OCA].
 ==Reference==
-An atomic resolution model for assembly, architecture, and function of the Dr adhesins., Anderson KL, Billington J, Pettigrew D, Cota E, Simpson P, Roversi P, Chen HA, Urvil P, du Merle L, Barlow PN, Medof ME, Smith RA, Nowicki B, Le Bouguenec C, Lea SM, Matthews S, Mol Cell. 2004 Aug 27;15(4):647-57. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15327779 15327779]
+An atomic resolution model for assembly, architecture, and function of the Dr adhesins., Anderson KL, Billington J, Pettigrew D, Cota E, Simpson P, Roversi P, Chen HA, Urvil P, du Merle L, Barlow PN, Medof ME, Smith RA, Nowicki B, Le Bouguenec C, Lea SM, Matthews S, Mol Cell. 2004 Aug 27;15(4):647-57. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15327779 15327779]
 [[Category: Escherichia coli]]
 [[Category: Single protein]]
@@ Line 38: / Line 47: @@
 [[Category: upec]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:55:39 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:57:34 2008''