4en6: Difference between revisions

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-{{STRUCTURE_4en6|  PDB=4en6  |  SCENE=  }}
+==Crystal structure of HA70 (HA3) subcomponent of Clostridium botulinum type C progenitor toxin in complex with alpha 2-3-sialyllactose==
-===Crystal structure of HA70 (HA3) subcomponent of Clostridium botulinum type C progenitor toxin in complex with alpha 2-3-sialyllactose===
+<StructureSection load='4en6' size='340' side='right' caption='[[4en6]], [[Resolution|resolution]] 2.56&Aring;' scene=''>
-{{ABSTRACT_PUBMED_22684008}}
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4en6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EN6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EN6 FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2zs6|2zs6]], [[2zoe|2zoe]], [[4en7|4en7]], [[4en8|4en8]], [[4en9|4en9]]</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HA-70 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1491 Clostridium botulinum])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4en6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4en6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4en6 RCSB], [http://www.ebi.ac.uk/pdbsum/4en6 PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Clostridium botulinum produces the botulinum neurotoxin, forming a large complex as progenitor toxins in association with non-toxic non-hemagglutinin and/or several different hemagglutinin (HA) subcomponents, HA33, HA17 and HA70, which bind to carbohydrate of glycoproteins from epithelial cells in the infection process. To elucidate the carbohydrate recognition mechanism of HA70, X-ray structures of HA70 from type C toxin (HA70/C) in complexes with sialylated oligosaccharides were determined, and a binding assay by the glycoconjugate microarray was performed. These results suggested that HA70/C can recognize both alpha2-3- and alpha2-6-sialylated oligosaccharides, and that it has a higher affinity for alpha2-3-sialylated oligosaccharides.
-==About this Structure==
+Carbohydrate recognition mechanism of HA70 from Clostridium botulinum deduced from X-ray structures in complexes with sialylated oligosaccharides.,Yamashita S, Yoshida H, Uchiyama N, Nakakita Y, Nakakita S, Tonozuka T, Oguma K, Nishikawa A, Kamitori S FEBS Lett. 2012 Jul 30;586(16):2404-10. doi: 10.1016/j.febslet.2012.05.055. Epub , 2012 Jun 7. PMID:22684008<ref>PMID:22684008</ref>
-[[4en6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EN6 OCA].
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
 ==See Also==
 *[[Hemagglutinin|Hemagglutinin]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:022684008</ref><references group="xtra"/><references/>
+__TOC__
+</StructureSection>
 [[Category: Clostridium botulinum]]
-[[Category: Kamitori, S.]]
+[[Category: Kamitori, S]]
-[[Category: Nishikawa, A.]]
+[[Category: Nishikawa, A]]
-[[Category: Tonozuka, T.]]
+[[Category: Tonozuka, T]]
-[[Category: Yamashita, S.]]
+[[Category: Yamashita, S]]
-[[Category: Yoshida, H.]]
+[[Category: Yoshida, H]]
 [[Category: Carbohydrate/sugar binding]]
 [[Category: Sugar binding protein]]