1rmd: Difference between revisions

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File:1rmd.gif

, resolution 2.10Å

Ligands:

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RAG1 DIMERIZATION DOMAIN

OverviewOverview

The crystal structure of the dimerization domain of the V(D)J recombination-activating protein, RAG1, was solved using zinc anomalous scattering. The structure reveals an unusual combination of multi-class zinc-binding motifs, including a zinc RING finger and a C2H2 zinc finger, that together from a single structural domain. The domain also contains a unique zinc binuclear cluster in place of a normally mononuclear zinc site in the RING finger. Together, four zinc ions help organize the entire domain, including the two helices that form the dimer interface.

About this StructureAbout this Structure

1RMD is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of the RAG1 dimerization domain reveals multiple zinc-binding motifs including a novel zinc binuclear cluster., Bellon SF, Rodgers KK, Schatz DG, Coleman JE, Steitz TA, Nat Struct Biol. 1997 Jul;4(7):586-91. PMID:9228952

Page seeded by OCA on Thu Mar 20 13:53:35 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1rmd.gif|left|200px]]<br /><applet load="1rmd" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1rmd.gif|left|200px]]
-caption="1rmd, resolution 2.10&Aring;" />
-'''RAG1 DIMERIZATION DOMAIN'''<br />
+ {{Structure
+|PDB= 1rmd |SIZE=350|CAPTION= <scene name='initialview01'>1rmd</scene>, resolution 2.10&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene>
+|ACTIVITY=
+|GENE=
+}}
+'''RAG1 DIMERIZATION DOMAIN'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-RMD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RMD OCA].
+RMD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RMD OCA].
 ==Reference==
-Crystal structure of the RAG1 dimerization domain reveals multiple zinc-binding motifs including a novel zinc binuclear cluster., Bellon SF, Rodgers KK, Schatz DG, Coleman JE, Steitz TA, Nat Struct Biol. 1997 Jul;4(7):586-91. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9228952 9228952]
+Crystal structure of the RAG1 dimerization domain reveals multiple zinc-binding motifs including a novel zinc binuclear cluster., Bellon SF, Rodgers KK, Schatz DG, Coleman JE, Steitz TA, Nat Struct Biol. 1997 Jul;4(7):586-91. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9228952 9228952]
 [[Category: Mus musculus]]
 [[Category: Single protein]]
@@ Line 28: / Line 37: @@
 [[Category: zinc finger]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:52:25 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:53:35 2008''