3zfe: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Human enterovirus 71 in complex with capsid binding inhibitor WIN51711== | |||
===Human enterovirus 71 in | <StructureSection load='3zfe' size='340' side='right' caption='[[3zfe]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3zfe]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ev-71 Ev-71]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZFE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZFE FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SPH:SPHINGOSINE'>SPH</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3zff|3zff]], [[3zfg|3zfg]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zfe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zfe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zfe RCSB], [http://www.ebi.ac.uk/pdbsum/3zfe PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Human enterovirus 71 is a picornavirus causing hand, foot, and mouth disease that may progress to fatal encephalitis in infants and small children. As of now, no cure is available for enterovirus 71 infections. Small molecule inhibitors binding into a hydrophobic pocket within capsid viral protein 1 were previously shown to effectively limit infectivity of many picornaviruses. Here we report a 3.2-A-resolution X-ray structure of the enterovirus 71 virion complexed with the capsid-binding inhibitor WIN 51711. The inhibitor replaced the natural pocket factor within the viral protein 1 pocket without inducing any detectable rearrangements in the structure of the capsid. Furthermore, we show that the compound stabilizes enterovirus 71 virions and limits its infectivity, probably through restricting dynamics of the capsid necessary for genome release. Thus, our results provide a structural basis for development of antienterovirus 71 capsid-binding drugs. | |||
Structure of human enterovirus 71 in complex with a capsid-binding inhibitor.,Plevka P, Perera R, Yap ML, Cardosa J, Kuhn RJ, Rossmann MG Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5463-7. doi:, 10.1073/pnas.1222379110. Epub 2013 Mar 18. PMID:23509286<ref>PMID:23509286</ref> | |||
== | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | |||
[[Category: | == References == | ||
[[Category: Cardosa, J | <references/> | ||
[[Category: Kuhn, R J | __TOC__ | ||
[[Category: Perera, R | </StructureSection> | ||
[[Category: Plevka, P | [[Category: Ev-71]] | ||
[[Category: Rossmann, M G | [[Category: Cardosa, J]] | ||
[[Category: Yap, M L | [[Category: Kuhn, R J]] | ||
[[Category: Perera, R]] | |||
[[Category: Plevka, P]] | |||
[[Category: Rossmann, M G]] | |||
[[Category: Yap, M L]] | |||
[[Category: Ev71]] | [[Category: Ev71]] | ||
[[Category: Picornavirus]] | [[Category: Picornavirus]] | ||
[[Category: Virus]] | [[Category: Virus]] | ||
Revision as of 12:31, 21 December 2014
Human enterovirus 71 in complex with capsid binding inhibitor WIN51711Human enterovirus 71 in complex with capsid binding inhibitor WIN51711
Structural highlights
Publication Abstract from PubMedHuman enterovirus 71 is a picornavirus causing hand, foot, and mouth disease that may progress to fatal encephalitis in infants and small children. As of now, no cure is available for enterovirus 71 infections. Small molecule inhibitors binding into a hydrophobic pocket within capsid viral protein 1 were previously shown to effectively limit infectivity of many picornaviruses. Here we report a 3.2-A-resolution X-ray structure of the enterovirus 71 virion complexed with the capsid-binding inhibitor WIN 51711. The inhibitor replaced the natural pocket factor within the viral protein 1 pocket without inducing any detectable rearrangements in the structure of the capsid. Furthermore, we show that the compound stabilizes enterovirus 71 virions and limits its infectivity, probably through restricting dynamics of the capsid necessary for genome release. Thus, our results provide a structural basis for development of antienterovirus 71 capsid-binding drugs. Structure of human enterovirus 71 in complex with a capsid-binding inhibitor.,Plevka P, Perera R, Yap ML, Cardosa J, Kuhn RJ, Rossmann MG Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5463-7. doi:, 10.1073/pnas.1222379110. Epub 2013 Mar 18. PMID:23509286[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
|
| ||||||||||||||||||