1re8: Difference between revisions

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[[Image:1re8.gif|left|200px]]<br /><applet load="1re8" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1re8.gif|left|200px]]
caption="1re8, resolution 2.1&Aring;" />
 
'''Crystal structure of cAMP-dependent protein kinase complexed with balanol analog 2'''<br />
{{Structure
|PDB= 1re8 |SIZE=350|CAPTION= <scene name='initialview01'>1re8</scene>, resolution 2.1&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=BD2:3-[(4-HYDROXYBENZOYL)AMINO]AZEPAN-4-YL+4-(2-HYDROXYBENZOYL)BENZOATE'>BD2</scene> and <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1]
|GENE= PRKACA, PKACA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
}}
 
'''Crystal structure of cAMP-dependent protein kinase complexed with balanol analog 2'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1RE8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=BD2:'>BD2</scene> and <scene name='pdbligand=OCT:'>OCT</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RE8 OCA].  
1RE8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RE8 OCA].  


==Reference==
==Reference==
Balanol analogues probe specificity determinants and the conformational malleability of the cyclic 3',5'-adenosine monophosphate-dependent protein kinase catalytic subunit., Akamine P, Madhusudan, Brunton LL, Ou HD, Canaves JM, Xuong NH, Taylor SS, Biochemistry. 2004 Jan 13;43(1):85-96. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14705934 14705934]
Balanol analogues probe specificity determinants and the conformational malleability of the cyclic 3',5'-adenosine monophosphate-dependent protein kinase catalytic subunit., Akamine P, Madhusudan, Brunton LL, Ou HD, Canaves JM, Xuong NH, Taylor SS, Biochemistry. 2004 Jan 13;43(1):85-96. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14705934 14705934]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: natural product inhibitor]]
[[Category: natural product inhibitor]]
[[Category: protein kinase]]
[[Category: protein kinase]]
[[Category: specificity determinants]]
[[Category: specificity determinant]]


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