1r6j: Difference between revisions

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Revision as of 14:47, 20 March 2008

File:1r6j.gif

, resolution 0.73Å

Ligands:

Gene:

SDCBP OR MDA9 OR SYCL (Homo sapiens)

Coordinates:

save as pdb, mmCIF, xml

Ultrahigh resolution Crystal Structure of syntenin PDZ2

OverviewOverview

The crystal structure of the second PDZ domain of the scaffolding protein syntenin was solved using data extending to 0.73 A resolution. The crystallographic model, including the hydrogen atoms and the anisotropic displacement parameters, was refined to a conventional R-factor of 7.5% and Rfree of 8.7%, making it the most precise crystallographic model of a protein molecule to date. The model reveals discrete disorder in several places in the molecule, and significant plasticity of the peptide bond, with some omega angles deviating by nearly 20 degrees from planarity. Most hydrogen atoms are easily identifiable in the electron density and weak hydrogen bonds of the C-H...O type are clearly visible between the beta-strands. The study sets a new standard for high-resolution protein crystallography.

About this StructureAbout this Structure

1R6J is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

The PDZ2 domain of syntenin at ultra-high resolution: bridging the gap between macromolecular and small molecule crystallography., Kang BS, Devedjiev Y, Derewenda U, Derewenda ZS, J Mol Biol. 2004 Apr 30;338(3):483-93. PMID:15081807

Page seeded by OCA on Thu Mar 20 13:47:36 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1r6j.gif|left|200px]]<br /><applet load="1r6j" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1r6j.gif|left|200px]]
-caption="1r6j, resolution 0.73&Aring;" />
-'''Ultrahigh resolution Crystal Structure of syntenin PDZ2'''<br />
+ {{Structure
+|PDB= 1r6j |SIZE=350|CAPTION= <scene name='initialview01'>1r6j</scene>, resolution 0.73&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=CL:CHLORIDE ION'>CL</scene>
+|ACTIVITY=
+|GENE= SDCBP OR MDA9 OR SYCL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+}}
+'''Ultrahigh resolution Crystal Structure of syntenin PDZ2'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-R6J is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CL:'>CL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R6J OCA].
+R6J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R6J OCA].
 ==Reference==
-The PDZ2 domain of syntenin at ultra-high resolution: bridging the gap between macromolecular and small molecule crystallography., Kang BS, Devedjiev Y, Derewenda U, Derewenda ZS, J Mol Biol. 2004 Apr 30;338(3):483-93. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15081807 15081807]
+The PDZ2 domain of syntenin at ultra-high resolution: bridging the gap between macromolecular and small molecule crystallography., Kang BS, Devedjiev Y, Derewenda U, Derewenda ZS, J Mol Biol. 2004 Apr 30;338(3):483-93. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15081807 15081807]
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
@@ Line 20: / Line 29: @@
 [[Category: pdz]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:47:37 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:47:36 2008''