1r02: Difference between revisions
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'''Solution structure of Human Orexin-A:Regulator of Appetite and Wakefulness''' | {{Structure | ||
|PDB= 1r02 |SIZE=350|CAPTION= <scene name='initialview01'>1r02</scene> | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= | |||
|GENE= | |||
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'''Solution structure of Human Orexin-A:Regulator of Appetite and Wakefulness''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1R02 is a [ | 1R02 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R02 OCA]. | ||
==Reference== | ==Reference== | ||
Solution structure of human orexin-A: regulator of appetite and wakefulness., Kim HY, Hong E, Kim JI, Lee W, J Biochem Mol Biol. 2004 Sep 30;37(5):565-73. PMID:[http:// | Solution structure of human orexin-A: regulator of appetite and wakefulness., Kim HY, Hong E, Kim JI, Lee W, J Biochem Mol Biol. 2004 Sep 30;37(5):565-73. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15479620 15479620] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Hong, E.]] | [[Category: Hong, E.]] | ||
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[[Category: turn]] | [[Category: turn]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:45:02 2008'' | ||
Revision as of 14:45, 20 March 2008
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Solution structure of Human Orexin-A:Regulator of Appetite and Wakefulness
OverviewOverview
Orexin-A and orexin-B (hypocretin-1 and hypocretin-2, respectively) are important hypothalamic neuro-peptides, which are encoded by a single mRNA transcript and stimulate food intake as well as regulate wakefulness. Here we determined the solution structure of orexin-A by NMR spectroscopy and by simulated-annealing calculation. The structural features of orexin-A involve two alpha-helices, with the hydrophobic residues disposed to on one side of helix, and hydrophilic residues to the other. A hydrophilic turn induced by two disulfide bonds provides the key difference between orexin-A and -B. With previous mutagenic studies, the derived structure of orexin-A provides us with a structure-functional view for novel drug design.
DiseaseDisease
Known diseases associated with this structure: Narcolepsy OMIM:[602358], Porphyria variegata OMIM:[600923]
About this StructureAbout this Structure
1R02 is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
ReferenceReference
Solution structure of human orexin-A: regulator of appetite and wakefulness., Kim HY, Hong E, Kim JI, Lee W, J Biochem Mol Biol. 2004 Sep 30;37(5):565-73. PMID:15479620
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